TY - JOUR
T1 - Management of reproductive health in cowden syndrome complicated by endometrial polyps and breast cancer
AU - Kalin, Asli
AU - Merideth, Melissa A.
AU - Regier, Debra S.
AU - Blumenthal, Gideon M.
AU - Dennis, Phillip A.
AU - Stratton, Pamela
PY - 2013/2
Y1 - 2013/2
N2 - Background: Cowden syndrome is an autosomal-dominant condition associated with mutations in the tumor suppressor gene PTEN. Gynecologic malignancies are common with a 5-10% risk of endometrial cancer and 25-50% risk of breast cancer. Case: A 37-year-old woman with a history of breast cancer, other neoplasms, and multiple skin lesions was diagnosed with Cowden syndrome after a germline PTEN mutation was identified. The endometrium had high glucose uptake on positron emission tomography scan and was irregularly thickened on ultrasonography; biopsy revealed endometrial polyps and simple hyperplasia. Fifteen months later, hysteroscopy again confirmed numerous benign endometrial polyps. Conclusion: Recurrent, multiple endometrial polyps portend a high risk of endometrial cancer in women with Cowden syndrome. Monitoring for malignancy and consideration of hysterectomy after childbearing is completed is warranted. Clinical Trial Registration: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00971789.
AB - Background: Cowden syndrome is an autosomal-dominant condition associated with mutations in the tumor suppressor gene PTEN. Gynecologic malignancies are common with a 5-10% risk of endometrial cancer and 25-50% risk of breast cancer. Case: A 37-year-old woman with a history of breast cancer, other neoplasms, and multiple skin lesions was diagnosed with Cowden syndrome after a germline PTEN mutation was identified. The endometrium had high glucose uptake on positron emission tomography scan and was irregularly thickened on ultrasonography; biopsy revealed endometrial polyps and simple hyperplasia. Fifteen months later, hysteroscopy again confirmed numerous benign endometrial polyps. Conclusion: Recurrent, multiple endometrial polyps portend a high risk of endometrial cancer in women with Cowden syndrome. Monitoring for malignancy and consideration of hysterectomy after childbearing is completed is warranted. Clinical Trial Registration: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00971789.
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U2 - 10.1097/AOG.0b013e318270444f
DO - 10.1097/AOG.0b013e318270444f
M3 - Article
C2 - 23344409
AN - SCOPUS:84873862428
SN - 0029-7844
VL - 121
SP - 461
EP - 464
JO - Obstetrics and gynecology
JF - Obstetrics and gynecology
IS - 2 PART 2
ER -