Management of reproductive health in cowden syndrome complicated by endometrial polyps and breast cancer

Asli Kalin, Melissa A. Merideth, Debra S. Regier, Gideon M. Blumenthal, Phillip A. Dennis, Pamela Stratton

Research output: Contribution to journalArticle

Abstract

Background: Cowden syndrome is an autosomal-dominant condition associated with mutations in the tumor suppressor gene PTEN. Gynecologic malignancies are common with a 5-10% risk of endometrial cancer and 25-50% risk of breast cancer. Case: A 37-year-old woman with a history of breast cancer, other neoplasms, and multiple skin lesions was diagnosed with Cowden syndrome after a germline PTEN mutation was identified. The endometrium had high glucose uptake on positron emission tomography scan and was irregularly thickened on ultrasonography; biopsy revealed endometrial polyps and simple hyperplasia. Fifteen months later, hysteroscopy again confirmed numerous benign endometrial polyps. Conclusion: Recurrent, multiple endometrial polyps portend a high risk of endometrial cancer in women with Cowden syndrome. Monitoring for malignancy and consideration of hysterectomy after childbearing is completed is warranted. Clinical Trial Registration: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00971789.

Original languageEnglish (US)
Pages (from-to)461-464
Number of pages4
JournalObstetrics and gynecology
Volume121
Issue number2 PART 2
DOIs
StatePublished - Feb 1 2013

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Kalin, A., Merideth, M. A., Regier, D. S., Blumenthal, G. M., Dennis, P. A., & Stratton, P. (2013). Management of reproductive health in cowden syndrome complicated by endometrial polyps and breast cancer. Obstetrics and gynecology, 121(2 PART 2), 461-464. https://doi.org/10.1097/AOG.0b013e318270444f