Management of neovascular age-related macular degeneration: Current state-of-the-art care for optimizing visual outcomes and therapies in development

Aniruddha Agarwal; William R. Rhoades; Mostafa Hanout; Mohamed Kamel Soliman; Salman Sarwar; Mohammad Ali Sadiq; Yasir Jamal Sepah; Diana V. Do; Quan Dong Nguyen

doi:10.2147/OPTH.S74959

Management of neovascular age-related macular degeneration: Current state-of-the-art care for optimizing visual outcomes and therapies in development

Aniruddha Agarwal, William R. Rhoades, Mostafa Hanout, Mohamed Kamel Soliman, Salman Sarwar, Mohammad Ali Sadiq, Yasir Jamal Sepah, Diana V. Do, Quan Dong Nguyen

School of Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Contemporary management of neovascular age-related macular degeneration (AMD) has evolved significantly over the last few years. The goal of treatment is shifting from merely salvaging vision to maintaining a high quality of life. There have been significant breakthroughs in the identification of viable drug targets and gene therapies. Imaging tools with near-histological precision have enhanced our knowledge about pathophysiological mechanisms that play a role in vision loss due to AMD. Visual, social, and vocational rehabilitation are all important treatment goals. In this review, evidence from landmark clinical trials is summarized to elucidate the optimum modern-day management of neovascular AMD. Therapeutic strategies currently under development, such as gene therapy and personalized medicine, are also described.

Original language	English (US)
Pages (from-to)	1001-1015
Number of pages	15
Journal	Clinical Ophthalmology
Volume	9
DOIs	https://doi.org/10.2147/OPTH.S74959
State	Published - Jun 5 2015

Keywords

AMD
Choroidal neovascular membrane
Gene therapy
Low-vision rehabilitation
Neovascular AMD
Pharmacogenomics
VEGF

ASJC Scopus subject areas

Ophthalmology

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10.2147/OPTH.S74959

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title = "Management of neovascular age-related macular degeneration: Current state-of-the-art care for optimizing visual outcomes and therapies in development",

abstract = "Contemporary management of neovascular age-related macular degeneration (AMD) has evolved significantly over the last few years. The goal of treatment is shifting from merely salvaging vision to maintaining a high quality of life. There have been significant breakthroughs in the identification of viable drug targets and gene therapies. Imaging tools with near-histological precision have enhanced our knowledge about pathophysiological mechanisms that play a role in vision loss due to AMD. Visual, social, and vocational rehabilitation are all important treatment goals. In this review, evidence from landmark clinical trials is summarized to elucidate the optimum modern-day management of neovascular AMD. Therapeutic strategies currently under development, such as gene therapy and personalized medicine, are also described.",

keywords = "AMD, Choroidal neovascular membrane, Gene therapy, Low-vision rehabilitation, Neovascular AMD, Pharmacogenomics, VEGF",

author = "Aniruddha Agarwal and Rhoades, {William R.} and Mostafa Hanout and Soliman, {Mohamed Kamel} and Salman Sarwar and Sadiq, {Mohammad Ali} and Sepah, {Yasir Jamal} and Do, {Diana V.} and Nguyen, {Quan Dong}",

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doi = "10.2147/OPTH.S74959",

language = "English (US)",

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AU - Agarwal, Aniruddha

AU - Rhoades, William R.

AU - Hanout, Mostafa

AU - Soliman, Mohamed Kamel

AU - Sarwar, Salman

AU - Sadiq, Mohammad Ali

AU - Sepah, Yasir Jamal

AU - Do, Diana V.

AU - Nguyen, Quan Dong

PY - 2015/6/5

Y1 - 2015/6/5

N2 - Contemporary management of neovascular age-related macular degeneration (AMD) has evolved significantly over the last few years. The goal of treatment is shifting from merely salvaging vision to maintaining a high quality of life. There have been significant breakthroughs in the identification of viable drug targets and gene therapies. Imaging tools with near-histological precision have enhanced our knowledge about pathophysiological mechanisms that play a role in vision loss due to AMD. Visual, social, and vocational rehabilitation are all important treatment goals. In this review, evidence from landmark clinical trials is summarized to elucidate the optimum modern-day management of neovascular AMD. Therapeutic strategies currently under development, such as gene therapy and personalized medicine, are also described.

AB - Contemporary management of neovascular age-related macular degeneration (AMD) has evolved significantly over the last few years. The goal of treatment is shifting from merely salvaging vision to maintaining a high quality of life. There have been significant breakthroughs in the identification of viable drug targets and gene therapies. Imaging tools with near-histological precision have enhanced our knowledge about pathophysiological mechanisms that play a role in vision loss due to AMD. Visual, social, and vocational rehabilitation are all important treatment goals. In this review, evidence from landmark clinical trials is summarized to elucidate the optimum modern-day management of neovascular AMD. Therapeutic strategies currently under development, such as gene therapy and personalized medicine, are also described.

KW - AMD

KW - Choroidal neovascular membrane

KW - Gene therapy

KW - Low-vision rehabilitation

KW - Neovascular AMD

KW - Pharmacogenomics

KW - VEGF

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Management of neovascular age-related macular degeneration: Current state-of-the-art care for optimizing visual outcomes and therapies in development

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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