Management of Lymph Nodes During Resection of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: A Systematic Review

Neda Amini, Aslam Ejaz, Gaya Spolverato, Shishir K. Maithel, Yuhree Kim, Timothy M. Pawlik

Research output: Contribution to journalArticle

Abstract

The role of lymph node dissection (LND) in the treatment of patients with hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICC) remains controversial. We sought to systematically review all available evidence to determine the role of LND in patients with HCC and ICC. Studies that reported on LND, lymph node metastasis (LNM), and short- and long-term outcomes for patients with HCC or ICC survival were identified from PubMed, Cochrane, Embase, Scopus, and Web of Science databases. Data were extracted, synthesized, and analyzed using standard techniques. A total of 603 and 434 references were identified for HCC and ICC, respectively. Among HCC patients, the overall prevalence of LND was 51.6 % (95 % confidence interval (CI) 19.7-83.5) with an associated LNM incidence of 44.5 % (95 % CI 27.4–61.7). LNM was associated with a 3- and 5-year survival of 27.5 and 20.8 %, respectively. Among ICC patients, most patients 78.5 % (95 % CI 76.2–80.7) underwent LND; 45.2 % (95 % CI 39.2–51.2) had LNM. Three and 5-year survival among ICC patients with LNM was 0.2 % (95 % CI 0–0.7) and 0 %, respectively. While there are insufficient data to recommend a routine LND in all patients with HCC or ICC, the potential prognostic value of LND suggests that LND should at least be considered at the time of surgery.

Original languageEnglish (US)
Pages (from-to)2136-2148
Number of pages13
JournalJournal of Gastrointestinal Surgery
Volume18
Issue number12
DOIs
StatePublished - Nov 18 2014

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Cholangiocarcinoma
Lymph Node Excision
Hepatocellular Carcinoma
Lymph Nodes
Confidence Intervals
Neoplasm Metastasis
Survival
PubMed
Databases
Incidence

Keywords

  • Hepatocellular carcinoma
  • Intrahepatic cholangiocarcinoma
  • Lymphadenectomy

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology
  • Medicine(all)

Cite this

Management of Lymph Nodes During Resection of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma : A Systematic Review. / Amini, Neda; Ejaz, Aslam; Spolverato, Gaya; Maithel, Shishir K.; Kim, Yuhree; Pawlik, Timothy M.

In: Journal of Gastrointestinal Surgery, Vol. 18, No. 12, 18.11.2014, p. 2136-2148.

Research output: Contribution to journalArticle

Amini, Neda ; Ejaz, Aslam ; Spolverato, Gaya ; Maithel, Shishir K. ; Kim, Yuhree ; Pawlik, Timothy M. / Management of Lymph Nodes During Resection of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma : A Systematic Review. In: Journal of Gastrointestinal Surgery. 2014 ; Vol. 18, No. 12. pp. 2136-2148.
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