Abstract
Metastatic insulinomas may present with recurrent life-threatening hypoglycemia. Treatment of hypoglycemia in such patients is difficult and frequently fails to respond to numerous therapeutic agents, requiring continuous dextrose infusion. The authors present our experience with Yttirum-90 radioembolization in a patient with metastatic malignant insulinoma who failed to respond to distal pancreatectomy, systemic chemotherapy with capecitabine and everolimus and medical treatment with somatostatin analogues, diazoxide and corticosteroids. Treatment with repeated Y-90 radioembolization resulted in rapid resolution of hypoglycemic events, allowing discontinuation of dextrose infusion and hospital discharge. However, the effect of Y-90 administration seems to be transient and without evidence of tumor shrinkage in imaging studies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 414-417 |
| Number of pages | 4 |
| Journal | American Journal of the Medical Sciences |
| Volume | 340 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2010 |
| Externally published | Yes |
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Keywords
- Hypoglycemia
- Insulinoma
- Malignant insulinoma
- Octreotide therapy
- Yttirum-90
ASJC Scopus subject areas
- Medicine(all)
Cite this
Management of intractable hypoglycemia with Yttirum-90 radioembolization in a patient with malignant insulinoma. / Chandra, Prakash; Yarandi, Shadi; Khazai, Natasha; Jacobs, Sol; Umpierrez, Guillermo E.
In: American Journal of the Medical Sciences, Vol. 340, No. 5, 01.01.2010, p. 414-417.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Management of intractable hypoglycemia with Yttirum-90 radioembolization in a patient with malignant insulinoma
AU - Chandra, Prakash
AU - Yarandi, Shadi
AU - Khazai, Natasha
AU - Jacobs, Sol
AU - Umpierrez, Guillermo E.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Metastatic insulinomas may present with recurrent life-threatening hypoglycemia. Treatment of hypoglycemia in such patients is difficult and frequently fails to respond to numerous therapeutic agents, requiring continuous dextrose infusion. The authors present our experience with Yttirum-90 radioembolization in a patient with metastatic malignant insulinoma who failed to respond to distal pancreatectomy, systemic chemotherapy with capecitabine and everolimus and medical treatment with somatostatin analogues, diazoxide and corticosteroids. Treatment with repeated Y-90 radioembolization resulted in rapid resolution of hypoglycemic events, allowing discontinuation of dextrose infusion and hospital discharge. However, the effect of Y-90 administration seems to be transient and without evidence of tumor shrinkage in imaging studies.
AB - Metastatic insulinomas may present with recurrent life-threatening hypoglycemia. Treatment of hypoglycemia in such patients is difficult and frequently fails to respond to numerous therapeutic agents, requiring continuous dextrose infusion. The authors present our experience with Yttirum-90 radioembolization in a patient with metastatic malignant insulinoma who failed to respond to distal pancreatectomy, systemic chemotherapy with capecitabine and everolimus and medical treatment with somatostatin analogues, diazoxide and corticosteroids. Treatment with repeated Y-90 radioembolization resulted in rapid resolution of hypoglycemic events, allowing discontinuation of dextrose infusion and hospital discharge. However, the effect of Y-90 administration seems to be transient and without evidence of tumor shrinkage in imaging studies.
KW - Hypoglycemia
KW - Insulinoma
KW - Malignant insulinoma
KW - Octreotide therapy
KW - Yttirum-90
UR - http://www.scopus.com/inward/record.url?scp=78349309297&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78349309297&partnerID=8YFLogxK
U2 - 10.1097/MAJ.0b013e3181ee7be2
DO - 10.1097/MAJ.0b013e3181ee7be2
M3 - Article
C2 - 20724903
AN - SCOPUS:78349309297
VL - 340
SP - 414
EP - 417
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
SN - 0002-9629
IS - 5
ER -