Management of cardiac sarcoidosis in 2020

Nisha Gilotra, David Okada, Apurva Sharma, Jonathan Chrispin

Research output: Contribution to journalArticlepeer-review

Abstract

Sarcoidosis is an inflammatory granulomatous disease that can affect any organ. Up to one-quarter of patients with systemic sarcoidosis may have evidence of cardiac involvement. The clinical manifestations of cardiac sarcoidosis (CS) include heart block, atrial arrhythmias, ventricular arrhythmias and heart failure. The diagnosis of CS can be challenging given the patchy infiltration of the myocardium but, with the increased availability of advanced cardiac imaging, more cases of CS are being identified. Immunosuppression with corticosteroids remains the standard therapy for the acute inflammatory phase of CS, but there is an evolving role of steroid-sparing agents. In this article, the authors provide an update on the diagnosis of CS, including the role of imaging; review the clinical manifestations of CS, namely heart block, atrial and ventricular arrhythmias and heart failure; discuss updated management strategies, including immunosuppression, electrophysiological and heart failure therapies; and identify the current gaps in knowledge and future directions for cardiac sarcoidosis.

Original languageEnglish (US)
Pages (from-to)182-188
Number of pages7
JournalArrhythmia and Electrophysiology Review
Volume9
Issue number4
DOIs
StatePublished - 2021

Keywords

  • Arrhythmias
  • Cardiac sarcoid
  • Heart failure
  • Immunosuppression
  • Sarcoid

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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