Management and Outcomes of Patients with Occlusive Thrombosis after Pediatric Cardiac Surgery Portions of the study were presented at the Canadian Cardiovascular Congress, October 27-31, 2012, Toronto, Ontario, Canada, and at the meeting of the Association for European Paediatric and Congenital Cardiology, May 23-26, 2012, Istanbul, Turkey.

Cedric Manlhiot, Leonardo R. Brandão, Steven M. Schwartz, V. Ben Sivarajan, Suzan Williams, Tanveer H. Collins, Brian W. McCrindle

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives To evaluate management and outcomes of thrombosis after pediatric cardiac surgery and stratify thrombi according to risk of short- and long-term complications to better guide therapeutic choices. Study design Retrospective review was performed of 513 thrombi (400 occlusive) diagnosed after 213 pediatric cardiac operations. Long-term outcomes over time were assessed with the use of parametric hazard regression models. Results Serious complications and/or high-intensity treatment occurred with 17%-24% of thrombi depending on location, most commonly in thrombi affecting the cardiac and cerebral circulation. Bleeding complications affected 13% of patients; associated factors included thrombolytics (OR 8.7, P <.001), greater daily dose of unfractionated heparin (OR 1.25 per 5 U/kg/day, P =.03), and extracorporeal support (OR 4.5, P =.007). Radiologic thrombus persistence was identified in 30% ± 3% at 12 months; associated factors included extracorporeal support (hazard ratio [HR] 1.9, P =.003), venous (HR 1.7, P =.003), and occlusive thrombi at presentation (HR 1.8, P =.001); greater oxygen saturation before surgery (HR 1.13/10%, P =.05) and thrombi in femoral veins (HR 1.9, P =.001) were associated with increased hazard of resolution. Freedom from postthrombotic syndrome was 83% ± 4% at 6 years, greater number of persistent vessel segment occlusions (HR 1.8/vessel, P =.001) and greater fibrinogen at diagnosis (HR 1.1 per g/L, P =.02) were associated with increased hazard. Conclusions Thrombosis outcomes after pediatric cardiac surgery remain suboptimal. Given that more intensive treatment would likely increase the risk of bleeding, the focus should be on both thrombosis-prevention strategies, as well as in tailoring therapy according to a thrombosis outcome risk stratification approach.

Original languageEnglish (US)
Pages (from-to)146-153
Number of pages8
JournalJournal of Pediatrics
Volume169
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Keywords

  • HR Hazard ratio

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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