Mammary ductal carcinoma with comedo pattern in a rhesus macaque

Joanne M. Smith, Srinivas S. Rao, Kyle C. Stump, Cinzia Benazzi, Giuseppe Sarli, Louis J. Detolla

Research output: Contribution to journalArticle

Abstract

A 23-year-old female rhesus macaque presented with a 2.5-cm diameter, firm, moveable, tabulated subcutaneous mass associated with a supranummary teat on the right side of the chest. This animal was a retired breeder, currently in an aging study. No exogenous hormone treatments were noted in the animal's history. Chest radiographs were within normal limits. Blood screens showed no noteworthy variations from normal. Needle aspirate cytology showed clusters of neoplastic cells. Grossly the mass was well circumscribed, firm, and homogeneously tan, with a glandular appearance. Differential diagnoses included sebaceous or mammary adenoma, carcinoma in situ, and lobular or ductular carcinoma. Histopathology was consistent with a mammary ductal carcinoma with comedo pattern. Subsequent needle aspirate cytology from an adjacent right axillary lymph node showed tumor cells with a few lymphoid cells, interpreted as lymphatic spread. Chest radiographs 2 and 6 weeks postbiopsy showed no evidence of pulmonary metastasis. After 1 year, there was no marked change on chest radiographs, but a small cluster of new nodules was palpable in the right axillary region. Histopathology of an excisional biopsy of the new nodules indicated tumor growth subjacent to regional lymph nodes. Further treatment was not performed and the animal remained clinically normal five years after the initial diagnosis. Spontaneous mammary neoplasia is a major concern in human medicine, yet it rarely has been reported to occur in nonhuman primates. This case is important in documenting an additional case of spontaneous mammary tumor development.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalContemporary Topics in Laboratory Animal Science
Volume44
Issue number4
StatePublished - Jul 2005
Externally publishedYes

Fingerprint

Carcinoma, Ductal, Breast
chest
Macaca mulatta
breast neoplasms
Thorax
cell biology
histopathology
breasts
carcinoma
Needles
lymph nodes
Cell Biology
Lymph Nodes
Neoplasms
animals
neoplasms
adenoma
mammary neoplasms (animal)
teats
metastasis

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Smith, J. M., Rao, S. S., Stump, K. C., Benazzi, C., Sarli, G., & Detolla, L. J. (2005). Mammary ductal carcinoma with comedo pattern in a rhesus macaque. Contemporary Topics in Laboratory Animal Science, 44(4), 29-33.

Mammary ductal carcinoma with comedo pattern in a rhesus macaque. / Smith, Joanne M.; Rao, Srinivas S.; Stump, Kyle C.; Benazzi, Cinzia; Sarli, Giuseppe; Detolla, Louis J.

In: Contemporary Topics in Laboratory Animal Science, Vol. 44, No. 4, 07.2005, p. 29-33.

Research output: Contribution to journalArticle

Smith, JM, Rao, SS, Stump, KC, Benazzi, C, Sarli, G & Detolla, LJ 2005, 'Mammary ductal carcinoma with comedo pattern in a rhesus macaque', Contemporary Topics in Laboratory Animal Science, vol. 44, no. 4, pp. 29-33.
Smith JM, Rao SS, Stump KC, Benazzi C, Sarli G, Detolla LJ. Mammary ductal carcinoma with comedo pattern in a rhesus macaque. Contemporary Topics in Laboratory Animal Science. 2005 Jul;44(4):29-33.
Smith, Joanne M. ; Rao, Srinivas S. ; Stump, Kyle C. ; Benazzi, Cinzia ; Sarli, Giuseppe ; Detolla, Louis J. / Mammary ductal carcinoma with comedo pattern in a rhesus macaque. In: Contemporary Topics in Laboratory Animal Science. 2005 ; Vol. 44, No. 4. pp. 29-33.
@article{ba300862c71c40c9a1c0a1f6a79b6f2f,
title = "Mammary ductal carcinoma with comedo pattern in a rhesus macaque",
abstract = "A 23-year-old female rhesus macaque presented with a 2.5-cm diameter, firm, moveable, tabulated subcutaneous mass associated with a supranummary teat on the right side of the chest. This animal was a retired breeder, currently in an aging study. No exogenous hormone treatments were noted in the animal's history. Chest radiographs were within normal limits. Blood screens showed no noteworthy variations from normal. Needle aspirate cytology showed clusters of neoplastic cells. Grossly the mass was well circumscribed, firm, and homogeneously tan, with a glandular appearance. Differential diagnoses included sebaceous or mammary adenoma, carcinoma in situ, and lobular or ductular carcinoma. Histopathology was consistent with a mammary ductal carcinoma with comedo pattern. Subsequent needle aspirate cytology from an adjacent right axillary lymph node showed tumor cells with a few lymphoid cells, interpreted as lymphatic spread. Chest radiographs 2 and 6 weeks postbiopsy showed no evidence of pulmonary metastasis. After 1 year, there was no marked change on chest radiographs, but a small cluster of new nodules was palpable in the right axillary region. Histopathology of an excisional biopsy of the new nodules indicated tumor growth subjacent to regional lymph nodes. Further treatment was not performed and the animal remained clinically normal five years after the initial diagnosis. Spontaneous mammary neoplasia is a major concern in human medicine, yet it rarely has been reported to occur in nonhuman primates. This case is important in documenting an additional case of spontaneous mammary tumor development.",
author = "Smith, {Joanne M.} and Rao, {Srinivas S.} and Stump, {Kyle C.} and Cinzia Benazzi and Giuseppe Sarli and Detolla, {Louis J.}",
year = "2005",
month = "7",
language = "English (US)",
volume = "44",
pages = "29--33",
journal = "Journal of the American Association for Laboratory Animal Science",
issn = "1559-6109",
publisher = "American Association for Laboratory Animal Science",
number = "4",

}

TY - JOUR

T1 - Mammary ductal carcinoma with comedo pattern in a rhesus macaque

AU - Smith, Joanne M.

AU - Rao, Srinivas S.

AU - Stump, Kyle C.

AU - Benazzi, Cinzia

AU - Sarli, Giuseppe

AU - Detolla, Louis J.

PY - 2005/7

Y1 - 2005/7

N2 - A 23-year-old female rhesus macaque presented with a 2.5-cm diameter, firm, moveable, tabulated subcutaneous mass associated with a supranummary teat on the right side of the chest. This animal was a retired breeder, currently in an aging study. No exogenous hormone treatments were noted in the animal's history. Chest radiographs were within normal limits. Blood screens showed no noteworthy variations from normal. Needle aspirate cytology showed clusters of neoplastic cells. Grossly the mass was well circumscribed, firm, and homogeneously tan, with a glandular appearance. Differential diagnoses included sebaceous or mammary adenoma, carcinoma in situ, and lobular or ductular carcinoma. Histopathology was consistent with a mammary ductal carcinoma with comedo pattern. Subsequent needle aspirate cytology from an adjacent right axillary lymph node showed tumor cells with a few lymphoid cells, interpreted as lymphatic spread. Chest radiographs 2 and 6 weeks postbiopsy showed no evidence of pulmonary metastasis. After 1 year, there was no marked change on chest radiographs, but a small cluster of new nodules was palpable in the right axillary region. Histopathology of an excisional biopsy of the new nodules indicated tumor growth subjacent to regional lymph nodes. Further treatment was not performed and the animal remained clinically normal five years after the initial diagnosis. Spontaneous mammary neoplasia is a major concern in human medicine, yet it rarely has been reported to occur in nonhuman primates. This case is important in documenting an additional case of spontaneous mammary tumor development.

AB - A 23-year-old female rhesus macaque presented with a 2.5-cm diameter, firm, moveable, tabulated subcutaneous mass associated with a supranummary teat on the right side of the chest. This animal was a retired breeder, currently in an aging study. No exogenous hormone treatments were noted in the animal's history. Chest radiographs were within normal limits. Blood screens showed no noteworthy variations from normal. Needle aspirate cytology showed clusters of neoplastic cells. Grossly the mass was well circumscribed, firm, and homogeneously tan, with a glandular appearance. Differential diagnoses included sebaceous or mammary adenoma, carcinoma in situ, and lobular or ductular carcinoma. Histopathology was consistent with a mammary ductal carcinoma with comedo pattern. Subsequent needle aspirate cytology from an adjacent right axillary lymph node showed tumor cells with a few lymphoid cells, interpreted as lymphatic spread. Chest radiographs 2 and 6 weeks postbiopsy showed no evidence of pulmonary metastasis. After 1 year, there was no marked change on chest radiographs, but a small cluster of new nodules was palpable in the right axillary region. Histopathology of an excisional biopsy of the new nodules indicated tumor growth subjacent to regional lymph nodes. Further treatment was not performed and the animal remained clinically normal five years after the initial diagnosis. Spontaneous mammary neoplasia is a major concern in human medicine, yet it rarely has been reported to occur in nonhuman primates. This case is important in documenting an additional case of spontaneous mammary tumor development.

UR - http://www.scopus.com/inward/record.url?scp=22844444503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22844444503&partnerID=8YFLogxK

M3 - Article

C2 - 16050665

AN - SCOPUS:22844444503

VL - 44

SP - 29

EP - 33

JO - Journal of the American Association for Laboratory Animal Science

JF - Journal of the American Association for Laboratory Animal Science

SN - 1559-6109

IS - 4

ER -