Mammalian telomere dynamics: healing, fragmentation shortening and stabilization

Research output: Contribution to journalArticle

Abstract

Telomeres are essential for stable chromosome maintenance. The simple G-rich sequence motif d(TTAGGG)n is all that is required in cis for telomere function in mammalian cells, as in other eukaryotes. Using this fact, telomeres have been used to specifically fragment mammalian chromosomes to dissect their structure and function. Telomere length maintenance is altered in cancer cells. Trans-acting factors, such as telomerase and telomere-binding proteins, may determine telomere function in both normal and cancer cells. Current experiments are aimed at understanding the role of telomerase and telomere-binding proteins in cellular senescence and immortalization.

Original languageEnglish (US)
Pages (from-to)203-211
Number of pages9
JournalCurrent Opinion in Genetics and Development
Volume4
Issue number2
DOIs
StatePublished - Apr 1994
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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