Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate

Adolfo Saiardi, Eiichiro Nagata, Hongbo R. Luo, Akira Sawa, Xiaojiang Luo, Adele M. Snowman, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mlPMK). By phosphorylating inositol 4,5-bisphosphate, mlPMK provides an alternative biosynthesis for inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]. mlPMK also can form the pyrophosphate disphosphoinositol tetrakisphosphate (PP-InsP4) from InsP5. Additionally, mlPMK forms InsP4 from Ins(1,4,5)P3 and InsP5 from Ins(1,3,4,5)P4.

Original languageEnglish (US)
Pages (from-to)2306-2311
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number5
DOIs
StatePublished - Feb 27 2001

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate'. Together they form a unique fingerprint.

  • Cite this