Malignant solitary fibrous tumor of the kidney: Report of a case and comprehensive review of the literature

Samson W. Fine, Denis M. McCarthy, Theresa Y. Chan, Jonathan I. Epstein, Pedram Argani

Research output: Contribution to journalReview articlepeer-review

Abstract

Renal solitary fibrous tumors (SFTs) have been reported infrequently. We report a 76-year-old man with a left renal mass that had previously been shown radiographically to be stable, but was now growing. Grossly, the mass measured 12 cm, was poorly circumscribed, and invaded beyond the renal capsule. Approximately 10% of the neoplasm consisted of haphazardly arranged spindle cells admixed with dense collagenous bands, which is typical of benign SFT. However, the remainder of the mass was composed of pleomorphic, spindled sarcoma cells with frequent mitoses and foci of necrosis, Immunohistochemically, we observed CD34 labeling in the benign SFT component with loss of expression in the sarcomatous component, focal labeling for Bcl-2 protein in both areas, and absence of labeling for cytokeratin, renal cell carcinoma marker, S100 protein, CD117, and muscle markers in both areas. To our knowledge, this is the first reported case of malignant renal SFT, likely representing transformation from a histologically documented benign SFT component.

Original languageEnglish (US)
Pages (from-to)857-861
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume130
Issue number6
StatePublished - Jun 1 2006

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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