Abstract
Malignant peripheral nerve sheath tumor (MPNST) is the sixth most common type of soft tissue sarcoma. Most MPNSTs arise in association with a peripheral nerve or preexisting neurofibroma. Neurofibromatosis type is the most important risk factor for MPNST. Tumor size and fludeoxyglucose F 18 avidity are among the most helpful parameters to distinguish MPNST from a benign peripheral nerve sheath tumor. The histopathologic diagnosis is predominantly a diagnosis of light microscopy. Immunohistochemical stains are most helpful to distinguish high-grade MPNST from its histologic mimics. Current surgical management of high-grade MPNST is similar to that of other high-grade soft tissue sarcomas.
Original language | English (US) |
---|---|
Pages (from-to) | 789-802 |
Number of pages | 14 |
Journal | Surgical Oncology Clinics of North America |
Volume | 25 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1 2016 |
Keywords
- Atypical neurofibroma
- Malignant peripheral nerve sheath tumor
- NF1
- Neurofibroma
- Neurofibromatosis
ASJC Scopus subject areas
- Surgery
- Oncology