Malignant melanoma in neo-bladder urinary cytology: A brief report

Srividya Sathiyamoorthy, Syed Z Ali

Research output: Contribution to journalArticle

Abstract

Malignant melanoma has an unusual predilection for metastasis to the small bowel, sometimes several years after the original diagnosis. In patients who have had a cystoprostatectomy followed by an ileal conduit, metastatic melanoma to the ileal conduit can present in urine cytology. We present a rare case of metastatic malignant melanoma in neo-bladder urine in a patient who had undergone a cystoprostatectomy for high grade urothelial carcinoma of the bladder and prostatic adenocarcinoma of Gleason grade 3+3 and two excisional procedures for cutaneous malignant melanoma. He presented with persistent hematuria and urinary tract infections unresponsive to treatment. Urine cytology revealed single large atypical cells, with large nuclei, prominent nucleoli, and cytoplasmic melanin pigment. Subsequent surgical resection revealed two areas of metastatic melanoma in the ileum, one of them being in the ileal conduit. The tumor cells were immunoreactive for S-100 protein, Melan-A, and HMB-45 and were negative for CAM5.2 and cytokeratins 7 and 20.

Original languageEnglish (US)
Pages (from-to)997-999
Number of pages3
JournalDiagnostic Cytopathology
Volume41
Issue number11
DOIs
StatePublished - Nov 2013

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Urinary Diversion
Cell Biology
Melanoma
Urinary Bladder
Urine
MART-1 Antigen
Keratin-20
Keratin-7
S100 Proteins
Melanins
Hematuria
Ileum
Urinary Tract Infections
Adenocarcinoma
Neoplasm Metastasis
Carcinoma
Neoplasms
Therapeutics

Keywords

  • ileal conduit
  • melanoma
  • metastatic
  • neo-bladder

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Malignant melanoma in neo-bladder urinary cytology : A brief report. / Sathiyamoorthy, Srividya; Ali, Syed Z.

In: Diagnostic Cytopathology, Vol. 41, No. 11, 11.2013, p. 997-999.

Research output: Contribution to journalArticle

Sathiyamoorthy, Srividya ; Ali, Syed Z. / Malignant melanoma in neo-bladder urinary cytology : A brief report. In: Diagnostic Cytopathology. 2013 ; Vol. 41, No. 11. pp. 997-999.
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