Hyperthermie maligne anesthésique

Translated title of the contribution: Malignant hyperthermia

J. F. Payen De La Garanderie, T. Depret, N. Monnier, Y. Nivoche, J. Lunardi, R. Krivosic-Horber

Research output: Contribution to journalArticle

Abstract

Our knowledge about malignant hyperthermia (MH) has been markedly improved since 10 years, primarily due to molecular genetics. Susceptibility to MH is based on an abnormal calcium metabolism within the skeletal muscle fibre. This is most probably caused by a defective calcium release channel in the sarcoplasmic reticulum, e.g. the ryanodine receptor. This defect is due to genetic mutations essentially located into the RYR1 gene. Mortality of MH crisis has been dramatically decreased since the widespread use of capnograph in operating theatre and the immediate infusion of dantrolene sodium. However, incomplete and non typical forms of MH do exist, and require further testing for MH susceptibility for the probant and his (her) family. The reference test is currently the in vitro contracture test (IVCT), which exposes muscle strips to incremental concentration of halothane and caffeine. Genetic analysis has emerged as a viable supplement to IVCT. Safe anesthesia for MH susceptible patients must avoid the use of volatile agents and succinylcholine. Central core disease and maybe exercise-induced rhabdomyolysis have an increased risk for MH susceptibility.

Original languageFrench
Pages (from-to)69-88
Number of pages20
JournalEMC - Anesthesie-Reanimation
Volume1
Issue number2
DOIs
StatePublished - Apr 2004
Externally publishedYes

Fingerprint

Malignant Hyperthermia
Contracture
Central Core Myopathy
Dantrolene
Ryanodine Receptor Calcium Release Channel
Rhabdomyolysis
Succinylcholine
Skeletal Muscle Fibers
Sarcoplasmic Reticulum
Halothane
Calcium Channels
Caffeine
Molecular Biology
Anesthesia
Exercise
Calcium
Muscles
Mutation
Mortality
Genes

Keywords

  • Anesthesia
  • Contracture test
  • Dantrolene
  • Genetics
  • Malignant hyperthermia

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Payen De La Garanderie, J. F., Depret, T., Monnier, N., Nivoche, Y., Lunardi, J., & Krivosic-Horber, R. (2004). Hyperthermie maligne anesthésique. EMC - Anesthesie-Reanimation, 1(2), 69-88. https://doi.org/10.1016/j.emcar.2004.02.001

Hyperthermie maligne anesthésique. / Payen De La Garanderie, J. F.; Depret, T.; Monnier, N.; Nivoche, Y.; Lunardi, J.; Krivosic-Horber, R.

In: EMC - Anesthesie-Reanimation, Vol. 1, No. 2, 04.2004, p. 69-88.

Research output: Contribution to journalArticle

Payen De La Garanderie, JF, Depret, T, Monnier, N, Nivoche, Y, Lunardi, J & Krivosic-Horber, R 2004, 'Hyperthermie maligne anesthésique', EMC - Anesthesie-Reanimation, vol. 1, no. 2, pp. 69-88. https://doi.org/10.1016/j.emcar.2004.02.001
Payen De La Garanderie JF, Depret T, Monnier N, Nivoche Y, Lunardi J, Krivosic-Horber R. Hyperthermie maligne anesthésique. EMC - Anesthesie-Reanimation. 2004 Apr;1(2):69-88. https://doi.org/10.1016/j.emcar.2004.02.001
Payen De La Garanderie, J. F. ; Depret, T. ; Monnier, N. ; Nivoche, Y. ; Lunardi, J. ; Krivosic-Horber, R. / Hyperthermie maligne anesthésique. In: EMC - Anesthesie-Reanimation. 2004 ; Vol. 1, No. 2. pp. 69-88.
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