Malignant fibrous histiocytoma associated with bone infarcts. Report of a case

R. H. Michael, H. D. Dorfman

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45 Scopus citations


Sarcoma formation at the site of a bone infarct has received increasing attention in the literature. Although quite rare, it has become apparent that there is a direct relation between bone infarcts and the subsequent development of bone sarcoma, especially in caisson workers. There is recent convincing evidence that the tissue origin of this tumor is predominantly histiocytic rather than fibrous in nature; hence, the designation malignant fibrous histiocytoma. A description is given of a caisson worker, with symmetrical bone infarcts in the tibiae, who demonstrated a malignant transformation of one of the bone infarcts with wide spread metastases to the lungs and viscera. Histologically, the tumor was found to be a malignant fibrous histiocytoma and despite amputation, the patient died approximately 1 yr following the diagnosis.

Original languageEnglish (US)
Pages (from-to)180-183
Number of pages4
JournalClinical orthopaedics and related research
VolumeNo. 118
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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