Abstract
The establishment of an in vitro model for cutaneous T cell lymphomas and Sézary syndrome has been difficult since T cells from individuals with these diseases do not proliferate in response to T cell mitogens. We found that conditioned media, collected from mitogen-activated PBMC from Sézary patients, contain an IL-2 receptor inducing factor. Despite their ostensible proliferative disorder, using a combination Sézary cell-conditioned media and rIL-2, we established IL-2 responsive, human T cell lymphotropic virus type I negative T cell lines from 23 patients, nine of which contain cells with the structural and/or genetic characteristics of neoplastic Sézary T cells.
Original language | English (US) |
---|---|
Pages (from-to) | 1455-1462 |
Number of pages | 8 |
Journal | Journal of Immunology |
Volume | 146 |
Issue number | 5 |
State | Published - Mar 1 1991 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology