TY - JOUR
T1 - Malignancies in HIV/AIDS patients attending an outpatient clinic in vitória, state of Espírito santo, Brazil
AU - Da Silva Pinto Neto, Lauro Ferreira
AU - Da Conceição Milanez, Maria
AU - Golub, Jonathan Eric
AU - Miranda, Angelica Espinosa Barbosa
PY - 2012/11
Y1 - 2012/11
N2 - Introduction: The present study investigated cancer prevalence and associated factors among HIV-infected individuals attending an AIDS outpatient clinic in Vitória, State of Espírito Santo, Brazil. Methods: A sectional study was conducted among HIV infected adults attending an AIDS outpatient clinic in Vitória, State of Espírito Santo, Brazil. Demographic, epidemiological and clinical data were abstracted from medical records, including cancer diagnoses; nadir and current CD4 cell count, HIV viral load, time on antiretroviral treatment (ART), type of ART and smoking status. Results: A total of 730 (91.3%) patients were included in the study. Median age was 44.0 [interquartile range (IQR): 35-50.3] years; median time since HIV diagnosis was 5.5 years (IQR: 2-10); 60% were male; and 59% were white. Thirty (4.1%) cases of cancer were identified of which 16 (53%) were AIDS defining cancers and 14 (47%) were non-AIDS defining malignancies. Patients diagnosed with cancer presented higher chance of being tobacco users [OR 2.2 (95% CI: 1.04-6.24)]; having nadir CD4 ≤200 cells/mm3 [OR 3.0 (95% CI: 1.19-7.81)] and higher lethality [OR 13, 3 (95% CI: 4, 57-38, 72)]. Conclusions: These results corroborate the importance of screening for and prevention of non-AIDS defining cancers focus in HIV-infected population, as these cancers presented with similar frequency as AIDS defining cancers.
AB - Introduction: The present study investigated cancer prevalence and associated factors among HIV-infected individuals attending an AIDS outpatient clinic in Vitória, State of Espírito Santo, Brazil. Methods: A sectional study was conducted among HIV infected adults attending an AIDS outpatient clinic in Vitória, State of Espírito Santo, Brazil. Demographic, epidemiological and clinical data were abstracted from medical records, including cancer diagnoses; nadir and current CD4 cell count, HIV viral load, time on antiretroviral treatment (ART), type of ART and smoking status. Results: A total of 730 (91.3%) patients were included in the study. Median age was 44.0 [interquartile range (IQR): 35-50.3] years; median time since HIV diagnosis was 5.5 years (IQR: 2-10); 60% were male; and 59% were white. Thirty (4.1%) cases of cancer were identified of which 16 (53%) were AIDS defining cancers and 14 (47%) were non-AIDS defining malignancies. Patients diagnosed with cancer presented higher chance of being tobacco users [OR 2.2 (95% CI: 1.04-6.24)]; having nadir CD4 ≤200 cells/mm3 [OR 3.0 (95% CI: 1.19-7.81)] and higher lethality [OR 13, 3 (95% CI: 4, 57-38, 72)]. Conclusions: These results corroborate the importance of screening for and prevention of non-AIDS defining cancers focus in HIV-infected population, as these cancers presented with similar frequency as AIDS defining cancers.
KW - Brazil
KW - HIV/AIDS
KW - Malignancies
KW - Prevalence
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U2 - 10.1590/S0037-86822012000600006
DO - 10.1590/S0037-86822012000600006
M3 - Article
C2 - 23295869
AN - SCOPUS:84872282256
SN - 0037-8682
VL - 45
SP - 687
EP - 690
JO - Revista da Sociedade Brasileira de Medicina Tropical
JF - Revista da Sociedade Brasileira de Medicina Tropical
IS - 6
ER -