Male survivors of allogeneic hematopoietic stem cell transplantation have a long term persisting risk of cardiovascular events

Priyanka A. Pophali, Jeffrey K. Klotz, Sawa Ito, Natasha A. Jain, Eleftheria Koklanaris, Robert Q. Le, Christopher S. Hourigan, Bipin N. Savani, Kamna Chawla, Sujata Shanbhag, A. John Barrett, Minoo Battiwalla

Research output: Contribution to journalArticlepeer-review

Abstract

Long-term survivors of allogeneic stem cell transplantation (SCT) have increased risk of cardiovascular disease. We retrospectively studied cardiovascular risk factors (CVRFs) in 109 SCT survivors (62 males, 47 females; median age 34 years) five years or more after bone marrow (15) or T cell-depleted peripheral blood (94) SCT for CML (56), acute leukemia (29), MDS (13), and others (11). One death and two cardiovascular events were reported. At five and ten years after SCT, respectively, 44% and 52% had abnormal lipid profiles; 23% of 5-year survivors met the Adult Treatment Panel III threshold for dyslipidemia treatment, which is substantially higher than the age-matched general population. There were significant increases in prevalence of hypertension (p < 0.001), diabetes (p = 0.018), and body mass index (p = 0.044) after SCT compared with baseline. The Framingham general cardiovascular risk score (FGCRS) in males at five years after SCT projected a doubling (median 10.4% vs. 5.4%) in the 10-year risk of cardiovascular events. Females received HRT after SCT, and none had increased FGCRS. Chronic GVHD and C-reactive protein were not associated with CVRF at any time. All CVRFs stabilized between five and ten years after SCT. Thus, SCT survivors have sustained elevations in CVRFs. Males have a significantly increased risk of cardiovascular events in their second and third decade after SCT.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalExperimental Hematology
Volume42
Issue number2
DOIs
StatePublished - Feb 2014
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

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