Male sterility induced by ethanol injection into the vas deferens

C. Freeman, D. S. Coffey

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A new approach to rapid male sterilization has been developed in rats. This involves chemical induction of obstruction of the vas deferens by injection of 50 microliters of sclerosing agents directly into the vas. A wide variety of sclerosing agents have been tested and 95% ethanol appears to produce complete blockage of the vas in a large series of animals. Long term sterility has been determined through mating. In addition, ejaculates have been confirmed to be completely free of sperm following treatment. The pathological changes produced in the vas by these sclerosing agents are described. This procedure can be accomplished in human cadavers without surgery by direct injection through the scrotum into the vas. This new technique is rapid and effective, and may be applicable to massive voluntary sterilization programs in underdeveloped countries.

Original languageEnglish (US)
Pages (from-to)129-132
Number of pages4
JournalInternational journal of fertility
Issue number3
StatePublished - Dec 1 1973

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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