Male reproductive health in cystic fibrosis

John C. Yoon; Julio Leey Casella; Marina Litvin; Adrian S. Dobs

doi:10.1016/j.jcf.2019.08.007

Male reproductive health in cystic fibrosis

John C. Yoon, Julio Leey Casella, Marina Litvin, Adrian S. Dobs

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The impact of cystic fibrosis (CF) on male reproductive health is profound. The vast majority of men with CF are infertile due to obstructive azoospermia. Multiple factors associated with CF contribute to an increased prevalence of testosterone deficiency, which adversely affects muscle mass, bone density, and quality of life. This article reviews the pathophysiology, diagnosis, and management of infertility and testosterone deficiency that occur in men with CF. With improving survival of CF patients, these topics are becoming more significant in their clinical care.

Original language	English (US)
Pages (from-to)	S105-S110
Journal	Journal of Cystic Fibrosis
Volume	18
DOIs	https://doi.org/10.1016/j.jcf.2019.08.007
State	Published - Oct 2019

Keywords

Cystic fibrosis
Hypogonadism
Infertility
Obstructive azoospermia
Testosterone deficiency

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine

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10.1016/j.jcf.2019.08.007

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title = "Male reproductive health in cystic fibrosis",

abstract = "The impact of cystic fibrosis (CF) on male reproductive health is profound. The vast majority of men with CF are infertile due to obstructive azoospermia. Multiple factors associated with CF contribute to an increased prevalence of testosterone deficiency, which adversely affects muscle mass, bone density, and quality of life. This article reviews the pathophysiology, diagnosis, and management of infertility and testosterone deficiency that occur in men with CF. With improving survival of CF patients, these topics are becoming more significant in their clinical care.",

keywords = "Cystic fibrosis, Hypogonadism, Infertility, Obstructive azoospermia, Testosterone deficiency",

author = "Yoon, {John C.} and Casella, {Julio Leey} and Marina Litvin and Dobs, {Adrian S.}",

note = "Funding Information: The authors would like to thank the Cystic Fibrosis Foundation for grant support through the Emerging Leaders in CF Endocrinology Program. Publisher Copyright: {\textcopyright} 2019 European Cystic Fibrosis Society",

year = "2019",

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doi = "10.1016/j.jcf.2019.08.007",

language = "English (US)",

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T1 - Male reproductive health in cystic fibrosis

AU - Yoon, John C.

AU - Casella, Julio Leey

AU - Litvin, Marina

AU - Dobs, Adrian S.

N1 - Funding Information: The authors would like to thank the Cystic Fibrosis Foundation for grant support through the Emerging Leaders in CF Endocrinology Program. Publisher Copyright: © 2019 European Cystic Fibrosis Society

PY - 2019/10

Y1 - 2019/10

N2 - The impact of cystic fibrosis (CF) on male reproductive health is profound. The vast majority of men with CF are infertile due to obstructive azoospermia. Multiple factors associated with CF contribute to an increased prevalence of testosterone deficiency, which adversely affects muscle mass, bone density, and quality of life. This article reviews the pathophysiology, diagnosis, and management of infertility and testosterone deficiency that occur in men with CF. With improving survival of CF patients, these topics are becoming more significant in their clinical care.

AB - The impact of cystic fibrosis (CF) on male reproductive health is profound. The vast majority of men with CF are infertile due to obstructive azoospermia. Multiple factors associated with CF contribute to an increased prevalence of testosterone deficiency, which adversely affects muscle mass, bone density, and quality of life. This article reviews the pathophysiology, diagnosis, and management of infertility and testosterone deficiency that occur in men with CF. With improving survival of CF patients, these topics are becoming more significant in their clinical care.

KW - Cystic fibrosis

KW - Hypogonadism

KW - Infertility

KW - Obstructive azoospermia

KW - Testosterone deficiency

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VL - 18

SP - S105-S110

JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

ER -

Male reproductive health in cystic fibrosis

Abstract

Keywords

ASJC Scopus subject areas

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