TY - JOUR
T1 - Male-female differences in the impact of β-adrenoceptor stimulation on resistance to experimental metastasis
T2 - Exploring the effects of age and gonadal hormone involvement
AU - Page, Gayle G.
AU - Fennelly, Andrea M.
AU - Littleton-Kearney, Marguerite T.
AU - Ben-Eliyahu, Shamgar
N1 - Funding Information:
We wish to acknowledge the excellent technical assistance of Wendy Blakely, Grace Ramaiah, and Deborah Wagner. This work was supported by NIH grant NR07742. Dr. Ben-Eliyahu was supported by NIH grant CA73056.
PY - 2008/1
Y1 - 2008/1
N2 - We studied the development of sexual dimorphism in resistance to NK-sensitive experimental metastasis under baseline conditions and following adrenoceptor stimulation. With increasing age, baseline resistance to MADB106 lung tumor retention (LTR) increased in both sexes, but also the susceptibility to the tumor-enhancing effects of a β-adrenergic agonist, metaproterenol. Beginning at 13 weeks, males exhibited a 2- to 3-fold greater increase in LTR than females following adrenoceptor stimulation. This adult dimorphism was robust to ovariectomy, and questionably related to androgens. The findings are consistent with reduced female responsiveness to sympathetic activation, and substantiate the importance of including both sexes when studying neuroimmunomodulation.
AB - We studied the development of sexual dimorphism in resistance to NK-sensitive experimental metastasis under baseline conditions and following adrenoceptor stimulation. With increasing age, baseline resistance to MADB106 lung tumor retention (LTR) increased in both sexes, but also the susceptibility to the tumor-enhancing effects of a β-adrenergic agonist, metaproterenol. Beginning at 13 weeks, males exhibited a 2- to 3-fold greater increase in LTR than females following adrenoceptor stimulation. This adult dimorphism was robust to ovariectomy, and questionably related to androgens. The findings are consistent with reduced female responsiveness to sympathetic activation, and substantiate the importance of including both sexes when studying neuroimmunomodulation.
KW - MADB106
KW - Sex differences
KW - Testosterone
KW - β-adrenergic
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U2 - 10.1016/j.jneuroim.2007.10.023
DO - 10.1016/j.jneuroim.2007.10.023
M3 - Article
C2 - 18037507
AN - SCOPUS:37749038714
SN - 0165-5728
VL - 193
SP - 113
EP - 119
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -