Male factor evaluation in in vitro fertilization: Norfolk experience

J. F H M van Uem, A. A. Acosta, R. J. Swanson, J. Mayer, S. Ackerman, L. J. Burkman, L. Veeck, J. S. McDowell, R. E. Bernardus, H. W. Jones

Research output: Contribution to journalArticle

Abstract

Thirty-three patients from the in vitro fertilization (IVF) program at Norfolk are critically reviewed. A battery of tests was designed and an endocrine investigation was carried out on these patients. The fertilization rate for preovulatory oocytes was lower than in the normal male population (39.6% versus 88.6%). When total concentration of sperm with rapidly progressive motility was <6 x 105, to fertilize several eggs together the fertilization rate was zero. No fertilization was obtained when the number of sperm with rapidly progressive motility recovered after the separation was <1.5 x 106. The hamster zona-free occyte penetration test correlated well with the human IVF system. The other parameters investigated did not show good correlation. When fertilization was achieved, the results of IVF procedure in the series reviewed rendered a 30.8% pregnancy rate per transfer in 26 transfers. Fifty percent of the pregnancies were normal (either ongoing or delivered). Thirty-seven percent were preclinical miscarriages, and 12.5% were clinical abortions. In the abnormal male population, higher concentrations of sperm per egg should be used for insemination for achievement of optimum fertilization rates. Once fertilization is obtained, the results do not differ substantially from the IVF population at large.

Original languageEnglish (US)
Pages (from-to)375-383
Number of pages9
JournalFertility and Sterility
Volume44
Issue number3
StatePublished - 1985
Externally publishedYes

Fingerprint

Fertilization in Vitro
Fertilization
Spermatozoa
Population
Sperm Count
Insemination
Herpes Zoster
Spontaneous Abortion
Pregnancy Rate
Cricetinae
Eggs
Oocytes
Ovum
Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

van Uem, J. F. H. M., Acosta, A. A., Swanson, R. J., Mayer, J., Ackerman, S., Burkman, L. J., ... Jones, H. W. (1985). Male factor evaluation in in vitro fertilization: Norfolk experience. Fertility and Sterility, 44(3), 375-383.

Male factor evaluation in in vitro fertilization : Norfolk experience. / van Uem, J. F H M; Acosta, A. A.; Swanson, R. J.; Mayer, J.; Ackerman, S.; Burkman, L. J.; Veeck, L.; McDowell, J. S.; Bernardus, R. E.; Jones, H. W.

In: Fertility and Sterility, Vol. 44, No. 3, 1985, p. 375-383.

Research output: Contribution to journalArticle

van Uem, JFHM, Acosta, AA, Swanson, RJ, Mayer, J, Ackerman, S, Burkman, LJ, Veeck, L, McDowell, JS, Bernardus, RE & Jones, HW 1985, 'Male factor evaluation in in vitro fertilization: Norfolk experience', Fertility and Sterility, vol. 44, no. 3, pp. 375-383.
van Uem JFHM, Acosta AA, Swanson RJ, Mayer J, Ackerman S, Burkman LJ et al. Male factor evaluation in in vitro fertilization: Norfolk experience. Fertility and Sterility. 1985;44(3):375-383.
van Uem, J. F H M ; Acosta, A. A. ; Swanson, R. J. ; Mayer, J. ; Ackerman, S. ; Burkman, L. J. ; Veeck, L. ; McDowell, J. S. ; Bernardus, R. E. ; Jones, H. W. / Male factor evaluation in in vitro fertilization : Norfolk experience. In: Fertility and Sterility. 1985 ; Vol. 44, No. 3. pp. 375-383.
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