Male circumcision decreases high-risk human papillomavirus viral load in female partners: A randomized trial in Rakai, Uganda

Mitzie Ann Davis, Ronald H. Gray, Mary K. Grabowski, David Serwadda, Godfrey Kigozi, Patti E. Gravitt, Fred Nalugoda, Stephen Watya, Maria J. Wawer, Thomas C. Quinn, Aaron A.R. Tobian

Research output: Contribution to journalArticlepeer-review

Abstract

Male circumcision (MC) reduces high-risk human papillomavirus (HR-HPV) infection in female partners. We evaluated the intensity of HR-HPV viral DNA load in HIV-negative, HR-HPV-positive female partners of circumcised and uncircumcised men. HIV-negative men and their female partners were enrolled in randomized trials of MC in Rakai, Uganda. Vaginal swabs were tested for HR-HPV genotypes by Roche HPV Linear Array which provides a semi-quantitative measure of HPV DNA by the intensity of genotype-specific bands (graded:1-4). We assessed the effects of MC on female HR-HPV DNA load by comparing high intensity linear array bands (3-4) to low intensity bands (1-2) using an intention-to-treat analysis. Prevalence risk ratios (PRR) of high intensity bands in partners of intervention versus control arm men were estimated using log-binomial regression with robust variance. The trial included 335 women with male partners in the intervention arm and 340 in the control arm. At enrollment, the frequency of HR-HPV high intensity linear array bands was similar in both study arms. At 24 months follow-up, the prevalence of high intensity bands among women with detectable HR-HPV was significantly lower in partners of intervention arm (42.7%) than control arm men (55.1%, PRR = 0.78, 95%CI 0.65-0.94, p = 0.02), primarily among incident HR-HPV infections (PRR = 0.66, 95% CI 0.50-0.87, p = 0.003), but not persistent infections (PRR = 1.02, 95% CI 0.83-1.24). Genotypes with high HR-HPV band intensity were more likely to persist (adjHR = 1.27 95% CI 1.07-1.50), irrespective of male partner circumcision status. MC reduces HR-HPV DNA load in newly infected female partners. What's new? Infection with human papillomavirus is linked to cervical cancer. Previous studies have shown that women married to circumcised men have lower rates of cervical cancer, but whether or not this is related to lower HPV load has never been reported. In this study, the authors measured HPV infection in HIV-negative women with circumcised and uncircumcised male partners. They found that HPV viral load was indeed lower in women whose male partners had been circumcised.

Original languageEnglish (US)
Pages (from-to)1247-1252
Number of pages6
JournalInternational Journal of Cancer
Volume133
Issue number5
DOIs
StatePublished - Sep 1 2013

Keywords

  • HIV
  • Uganda
  • cervical cancer
  • human papillomavirus
  • linear array band intensity
  • male circumcision
  • sexually transmitted infections
  • viral load
  • viral shedding

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Male circumcision decreases high-risk human papillomavirus viral load in female partners: A randomized trial in Rakai, Uganda'. Together they form a unique fingerprint.

Cite this