Male circumcision and risk of HIV-1 and other sexually transmitted infections in India

Steven J. Reynolds, Mary E. Shepherd, Arun R. Risbud, Raman R. Gangakhedkar, Ronald S. Brookmeyer, Anand D. Divekar, Sanjay M. Mehendale, Robert C. Bollinger

Research output: Contribution to journalArticle

Abstract

Circumcised men have a lower risk of HIV-1 infection than uncircumcised men. Laboratory findings suggest that the foreskin is enriched with HIV-1 target cells. However, some data suggest that circumcision could simply be a marker for low-risk behaviours. In a prospective study of 2298 HIV-uninfected men attending sexually transmitted infection clinics in India, we noted that circumcision was strongly protective against HIV-1 infection (adjusted relative risk 0·15; 95% CI 0·04-0·62; p=0·0089); however, we noted no protective effect against herpes simplex virus type 2, syphilis, or gonorrhoea. The specificity of this relation suggests a biological rather than behavioural explanation for the protective effect of male circumcision against HIV-1.

Original languageEnglish (US)
Pages (from-to)1039-1040
Number of pages2
JournalLancet
Volume363
Issue number9414
DOIs
StatePublished - Mar 27 2004

ASJC Scopus subject areas

  • Medicine(all)

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    Reynolds, S. J., Shepherd, M. E., Risbud, A. R., Gangakhedkar, R. R., Brookmeyer, R. S., Divekar, A. D., Mehendale, S. M., & Bollinger, R. C. (2004). Male circumcision and risk of HIV-1 and other sexually transmitted infections in India. Lancet, 363(9414), 1039-1040. https://doi.org/10.1016/S0140-6736(04)15840-6