Male circumcision and prevention of HIV and sexually transmitted infections

Ronald H. Gray, Maria J. Wawer, Chelsea B. Polis, Godfrey Kigozi, David Serwadda

Research output: Contribution to journalReview articlepeer-review

Abstract

Three randomized trials in Africa have shown that adult male circumcision reduces HIV acquisition in men by approximately 60%. It is biologically plausible that circumcision reduces HIV risk in men because the inner mucosa of the foreskin is lightly keratinized and has a high density of dendritic cells and other HIV target cells, making it vulnerable to HIV infection. Also, the foreskin is retracted over the shaft during intercourse, exposing the inner mucosa to vaginal secretions; the prepuce is vulnerable to trauma during coitus, providing a portal for HIV entry. In addition, circumcision reduces the rate of reported genital ulceration, which is a cofactor for HIV acquisition. Male circumcision may also reduce some other sexually transmitted infections in men and their female partners. For these reasons, male circumcision should be promoted as a component of HIV prevention strategies.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalCurrent Infectious Disease Reports
Volume10
Issue number2
DOIs
StatePublished - Mar 2008
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases

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