Male circumcision and herpes simplex virus type 2 infection in female partners: A randomized trial in Rakai, Uganda

Aaron A.R. Tobian, Godfrey Kigozi, Andrew D. Redd, David Serwadda, Xiangrong Kong, Amy Oliver, Fred Nalugoda, Thomas C. Quinn, Ronald H. Gray, Maria J. Wawer

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Abstract

Male circumcision reduces acquisition of herpes simplex virus type 2 (HSV-2) in men. We assessed whether male circumcision reduces HSV-2 infection among female partners. HSV-2-negative, human immunodeficiency virus-negative female partners of 368 males who were and 372 males who were not randomized to receive male circumcision were enrolled. The incidence of HSV-2 infection among females over a period of 2 years was 6.09 cases per 100 person-years in the intervention arm and 6.32 cases per 100 person-years in the control arm (incidence rate ratio [IRR], 0.96 [95% confidence interval {CI},. 62-1.49]; P =. 87). Among female partners of HSV-2-positive males, the incidence of HSV-2 infection was 9.55 cases per 100 person-years in the intervention arm and 11.17 cases per 100 person-years in the control arm (IRR, 0.85 [95% CI,. 44-1.67]; P =. 62). Contrary to findings in males, male circumcision did not affect HSV-2 acquisition among female partners.

Original languageEnglish (US)
Pages (from-to)486-490
Number of pages5
JournalJournal of Infectious Diseases
Volume205
Issue number3
DOIs
StatePublished - Feb 1 2012

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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