Male and female Drosophila germline stem cells: Two versions of immortality

Margaret T. Fuller, Allan C. Spradling

Research output: Contribution to journalArticle

Abstract

Drosophila male and female germline stem cells (GSCs) are sustained by niches and regulatory pathways whose common principles serve as models for understanding mammalian stem cells. Despite striking cellular and genetic similarities that suggest a common evolutionary origin, however, male and female GSCs also display important differences. Comparing these two stem cells and their niches in detail is likely to reveal how a common heritage has been adapted to the differing requirements of male and female gamete production.

Original languageEnglish (US)
Pages (from-to)402-404
Number of pages3
JournalScience
Volume316
Issue number5823
DOIs
StatePublished - Apr 20 2007
Externally publishedYes

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Drosophila
Stem Cell Niche
Germ Cells
Stem Cells
Oogonial Stem Cells

ASJC Scopus subject areas

  • General

Cite this

Male and female Drosophila germline stem cells : Two versions of immortality. / Fuller, Margaret T.; Spradling, Allan C.

In: Science, Vol. 316, No. 5823, 20.04.2007, p. 402-404.

Research output: Contribution to journalArticle

Fuller, Margaret T. ; Spradling, Allan C. / Male and female Drosophila germline stem cells : Two versions of immortality. In: Science. 2007 ; Vol. 316, No. 5823. pp. 402-404.
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