Malarial infection and curable sexually transmitted and reproductive tract infections among pregnant women in a rural district of Zambia

Enesia Banda Chaponda, R. Matthew Chico, Jane Bruce, Charles Michelo, Bellington Vwalika, Sungano Mharakurwa, Mike Chaponda, James Chipeta, Daniel Chandramohan

Research output: Contribution to journalArticle

Abstract

Malarial infection and curable sexually transmitted and reproductive tract infections (STIs/RTIs) are important causes of adverse birth outcomes. Reducing the burden of these infections in pregnancy requires interventions that can be easily integrated into the antenatal care (ANC) package. However, efforts to integrate the control of malarial infection and curable STIs/RTIs in pregnancy have been hampered by a lack of evidence related to their coinfection. Thus, we investigated the prevalence of coinfection among pregnant women of rural Zambia. A prospective cohort study was conducted in Nchelenge District, Zambia, involving 1,086 first ANC attendees. We screened participants for peripheral malarial infection and curable STIs/RTIs (syphilis, Chlamydia, gonorrhea, trichomoniasis, and bacterial vaginosis), and collected relevant sociodemographic data at booking. Factors associated with malarial and STI/RTI coinfection were explored using univariate and multivariate regression models. Among participants with complete results (N = 1,071), 38.7% (95% confidence interval [CI] = 35.7-41.6) were coinfected with malaria parasites and at least one STI/RTI; 18.9% (95% CI = 16.5-21.2) were infected with malaria parasites only; 26.0% (95% CI = 23.5-28.8) were infected with at least one STI/RTI but no malaria parasites, and 16.4% (95% CI = 14.1-18.6) had no infection. Human immunodeficiency virus (HIV)-infected women had a higher risk of being coinfected than HIV-uninfected women (odds ratio [OR] = 3.59 [95% CI = 1.73-7.48], P < 0.001). The prevalence of malarial and STI/RTI coinfection was high in this population. An integrated approach to control malarial infection and STIs/RTIs is needed to reduce this dual burden in pregnancy.

Original languageEnglish (US)
Pages (from-to)1069-1076
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume95
Issue number5
DOIs
StatePublished - Nov 1 2016

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Reproductive Tract Infections
Zambia
Sexually Transmitted Diseases
Pregnant Women
Coinfection
Confidence Intervals
Malaria
Parasites
Prenatal Care
Pregnancy
HIV
Bacterial Vaginosis
Chlamydia
Gonorrhea
Syphilis
Infection
Cohort Studies
Odds Ratio
Parturition
Prospective Studies

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Malarial infection and curable sexually transmitted and reproductive tract infections among pregnant women in a rural district of Zambia. / Chaponda, Enesia Banda; Matthew Chico, R.; Bruce, Jane; Michelo, Charles; Vwalika, Bellington; Mharakurwa, Sungano; Chaponda, Mike; Chipeta, James; Chandramohan, Daniel.

In: American Journal of Tropical Medicine and Hygiene, Vol. 95, No. 5, 01.11.2016, p. 1069-1076.

Research output: Contribution to journalArticle

Chaponda, EB, Matthew Chico, R, Bruce, J, Michelo, C, Vwalika, B, Mharakurwa, S, Chaponda, M, Chipeta, J & Chandramohan, D 2016, 'Malarial infection and curable sexually transmitted and reproductive tract infections among pregnant women in a rural district of Zambia', American Journal of Tropical Medicine and Hygiene, vol. 95, no. 5, pp. 1069-1076. https://doi.org/10.4269/ajtmh.16-0370
Chaponda, Enesia Banda ; Matthew Chico, R. ; Bruce, Jane ; Michelo, Charles ; Vwalika, Bellington ; Mharakurwa, Sungano ; Chaponda, Mike ; Chipeta, James ; Chandramohan, Daniel. / Malarial infection and curable sexually transmitted and reproductive tract infections among pregnant women in a rural district of Zambia. In: American Journal of Tropical Medicine and Hygiene. 2016 ; Vol. 95, No. 5. pp. 1069-1076.
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