Malaria-infected mice are cured by a single dose of novel artemisinin derivatives

Gary H. Posner, Ik Hyeon Paik, Wonsuk Chang, Kristina Borstnik, Sandra Sinishtaj, Andrew S. Rosenthal, Theresa A. Shapiro

Research output: Contribution to journalArticle

Abstract

We disclose here for the first time the curative activity of a new generation of trioxane dimers, designed logically and prepared easily from the natural trioxane artemisinin in only four or five chemical steps that would be easily accomplished also on a manufacturing scale. Four of these trioxane dimers cure malaria-infected mice after only a single subcutaneous dose, and two other dimers cure after three oral doses.

Original languageEnglish (US)
Pages (from-to)2516-2519
Number of pages4
JournalJournal of medicinal chemistry
Volume50
Issue number10
DOIs
StatePublished - May 17 2007

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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    Posner, G. H., Paik, I. H., Chang, W., Borstnik, K., Sinishtaj, S., Rosenthal, A. S., & Shapiro, T. A. (2007). Malaria-infected mice are cured by a single dose of novel artemisinin derivatives. Journal of medicinal chemistry, 50(10), 2516-2519. https://doi.org/10.1021/jm070149m