Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine

Rachel D. Slack, Bryan T. Mott, Lauren E. Woodard, Abhai Triphati, David Sullivan, Elizabeth Nenortas, Sonya C.T. Girdwood, Theresa A. Shapiro, Gary H. Posner

Research output: Contribution to journalArticle

Abstract

Sixteen new anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy in Plasmodium berghei infected mice. Of these 16 new anilides administered orally as one 6 mg/kg dose combined with 18 mg/kg mefloquine hydrochloride, only sulfide 3-arteSanilide 12d was completely curative: on day 30 after infection, all mice in this group had no detectable parasitemia, gained as much weight as the uninfected control mice, and behaved normally.

Original languageEnglish (US)
Pages (from-to)291-296
Number of pages6
JournalJournal of medicinal chemistry
Volume55
Issue number1
DOIs
StatePublished - Jan 12 2012

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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