Malabsorption of oral antibiotics in humans and rats with giardiasis

J. Carl Craft, Elizabeth A. Holt, Sheri H. Tan

Research output: Contribution to journalArticle

Abstract

We observed unexplained treatment failures in 13 patients with serious infections and apparent incidental giardiasis. Antibiotic concentrations were assayed in the serum from patients before initiating anti-Giardia therapy and again 2 to 3 weeks after therapy. The peak serum concentrations of antibiotics were higher after treatment for giardiasis. The rat model of giardiasis was used to examine the hypothesis that oral antibiotics are malabsorbed during Giardia lamblia infection. Twenty-eight-day-old Sprague-Dawley rats were fed amoxicillin (50 mg/kg/dose), ampicillin (50 mg/kg/dose), cefaclor (50 mg/kg/dose), cephalexin (50 mg/kg/ dose), erythromycin (50 mg/kg/dose), penicillin V (50 mg/kg/dose) or sulfamethoxazole (20 mg/ kg/dose) and sera were assayed for antibiotics at 1, 2, 4, 6 and 12 hours after therapy. The same rats were fed 105 G. lamblia cysts on 4 consecutive days. On Day 7 of infection the rats were fed the same antibiotic and sera were assayed for antibiotics at 1, 2, 4, 6 and 12 hours after th rapy. The mean peak serum concentrations for all drugs except sulfamethoxazole were significantly higher in the rats before infection with G. lamblia. These data suggest that oral antibiotic therapy maybe compromised by decreased absorption in the presence of giardiasis.

Original languageEnglish (US)
Pages (from-to)832-836
Number of pages5
JournalPediatric Infectious Disease Journal
Volume6
Issue number9
StatePublished - 1987
Externally publishedYes

Fingerprint

Giardiasis
Anti-Bacterial Agents
Giardia lamblia
Sulfamethoxazole
Serum
Infection
Penicillin V
Cefaclor
Cephalexin
Therapeutics
Giardia
Amoxicillin
Erythromycin
Ampicillin
Treatment Failure
Sprague Dawley Rats
Cysts
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Pediatrics, Perinatology, and Child Health

Cite this

Malabsorption of oral antibiotics in humans and rats with giardiasis. / Craft, J. Carl; Holt, Elizabeth A.; Tan, Sheri H.

In: Pediatric Infectious Disease Journal, Vol. 6, No. 9, 1987, p. 832-836.

Research output: Contribution to journalArticle

Craft, J. Carl ; Holt, Elizabeth A. ; Tan, Sheri H. / Malabsorption of oral antibiotics in humans and rats with giardiasis. In: Pediatric Infectious Disease Journal. 1987 ; Vol. 6, No. 9. pp. 832-836.
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