Making the most of it: Pathway reconstruction and integrative simulation using the data at hand

J. Jeremy Rice, Gustavo Stolovitzky

Research output: Contribution to journalReview article

Abstract

Pathway reconstruction is a fundamental task in systems biology toward an ultimate goal of full-scale in silico simulations. The data for such reconstructions is mostly lacking, but collection is underway for some model organisms. However, biological specificity might limit the ability to extrapolate findings. High-throughput data and methods might alleviate these problems, but only coarse or limited reconstructions are now possible. Inclusion of multiple data sources may improve the situation but remains a challenge.

Original languageEnglish (US)
Pages (from-to)70-77
Number of pages8
JournalDrug Discovery Today: BIOSILICO
Volume2
Issue number2
DOIs
StatePublished - Mar 1 2004

Keywords

  • Bayesian inference
  • gene expression
  • model
  • pathway reconstruction
  • reverse engineering
  • systems biology

ASJC Scopus subject areas

  • Drug Discovery

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