Making and repairing the mammalian brain - Signaling toward neurogenesis and gliogenesis

Y. E. Sun, K. Martinowich, W. Ge

Research output: Contribution to journalArticlepeer-review

Abstract

Neural stem cells (NSCs) are subscribed extraordinary potential in repair of the damaged nervous system. However, the molecular identity of NSCs has not been established. Most NSC cultures contain large numbers of multipotent, bipotent, and lineage restricted neural progenitors, the majority of which appear to lose neurogenic potential after expansion. This review first discusses the neurogenic to gliogenic switch that is characteristic of progenitor development in vivo and in NSC cultures, and then the cell intrinsic and extrinsic mechanisms regulating the sequential differentiation of neurons and glia. Finally, we discuss potential methods for maintaining the neurogenic potential of NSC cultures after expansion.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume14
Issue number3
DOIs
StatePublished - Jun 2003
Externally publishedYes

Keywords

  • Gliogenesis
  • Methylation
  • Neurogenesis
  • Stem cells
  • bHLH factors

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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