Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search

Jeffrey R. Smith, Diha Freije, John D. Carpten, Henrik Grönberg, Jianfeng Xu, Sarah D. Isaacs, Michael J. Brownstein, G. Steven Bova, Hong Guo, Piroska Bujnovszky, Deborah R. Nusskern, Jan Erik Damber, Anders Bergh, Monika Emanuelsson, Olli P. Kallioniemi, Jennifer Walker-Daniels, Joan E. Bailey-Wilson, Terri H. Beaty, Deborah A. Meyers, Patrick C. WalshFrancis S. Collins, Jeffrey M. Trent, William B. Isaacs

Research output: Contribution to journalArticlepeer-review

Abstract

Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high- risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.

Original languageEnglish (US)
Pages (from-to)1371-1374
Number of pages4
JournalScience
Volume274
Issue number5291
DOIs
StatePublished - Nov 22 1996
Externally publishedYes

ASJC Scopus subject areas

  • General

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