Major metabolites of (±)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons

Research output: Contribution to journalArticle

Abstract

The two major metabolites of (±)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (α-MeDA) and 3-O-methyl-α-methyldopamine (3-O-Me-α-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (α-MeDOPA and 3-O-Me-α-MeDOPA, respectively) were administered systemically, individually and in combination. None of these treatments produced a lasting depletion of brain serotonin (5-HT). These findings suggest that neither of MDA's major metabolites mediate its toxic effects on 5-HT neurons and that either a minor metabolite is responsible or that alternate mechanisms are involved.

Original languageEnglish (US)
Pages (from-to)279-282
Number of pages4
JournalBrain Research
Volume545
Issue number1-2
DOIs
StatePublished - Apr 5 1991

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3,4-Methylenedioxyamphetamine
Poisons
Serotonin
Neurons
Brain
Deoxyepinephrine

Keywords

  • Amphetamine
  • Methylenedioxyamphetamine
  • Neurotoxicity
  • Serotonin
  • α-Methyl-DOPA

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

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title = "Major metabolites of (±)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons",
abstract = "The two major metabolites of (±)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (α-MeDA) and 3-O-methyl-α-methyldopamine (3-O-Me-α-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (α-MeDOPA and 3-O-Me-α-MeDOPA, respectively) were administered systemically, individually and in combination. None of these treatments produced a lasting depletion of brain serotonin (5-HT). These findings suggest that neither of MDA's major metabolites mediate its toxic effects on 5-HT neurons and that either a minor metabolite is responsible or that alternate mechanisms are involved.",
keywords = "Amphetamine, Methylenedioxyamphetamine, Neurotoxicity, Serotonin, α-Methyl-DOPA",
author = "McCann, {Una D} and George Ricaurte",
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AU - Ricaurte, George

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N2 - The two major metabolites of (±)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (α-MeDA) and 3-O-methyl-α-methyldopamine (3-O-Me-α-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (α-MeDOPA and 3-O-Me-α-MeDOPA, respectively) were administered systemically, individually and in combination. None of these treatments produced a lasting depletion of brain serotonin (5-HT). These findings suggest that neither of MDA's major metabolites mediate its toxic effects on 5-HT neurons and that either a minor metabolite is responsible or that alternate mechanisms are involved.

AB - The two major metabolites of (±)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (α-MeDA) and 3-O-methyl-α-methyldopamine (3-O-Me-α-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (α-MeDOPA and 3-O-Me-α-MeDOPA, respectively) were administered systemically, individually and in combination. None of these treatments produced a lasting depletion of brain serotonin (5-HT). These findings suggest that neither of MDA's major metabolites mediate its toxic effects on 5-HT neurons and that either a minor metabolite is responsible or that alternate mechanisms are involved.

KW - Amphetamine

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