Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy

Falk Nimmerjahn, Slavoljub Milosevic, Uta Behrends, Elizabeth M. Jaffee, Drew M. Pardoll, Georg W. Bornkamm, Josef Mautner

Research output: Contribution to journalArticlepeer-review

Abstract

Biochemical and functional studies have demonstrated major histocompatibility complex (MHC) class II-restricted presentation of peptides derived from cytosolic proteins, but the underlying processing and presentation pathways have remained elusive. Here we show that endogenous presentation of an epitope derived from the cytosolic protein neomycin phosphotransferase II (NeoR) on MHC class II is mediated by autophagy. This presentation pathway involves the sequestration of NeoR into autophagosomes, and subsequent delivery into the lytic compartment. These results identify endosomes/lysosomes as the processing compartment for cytosolic antigens and furthermore link endogenous antigen presentation on MHC class II with the process of cellular protein turnover by autophagy.

Original languageEnglish (US)
Pages (from-to)1250-1259
Number of pages10
JournalEuropean Journal of Immunology
Volume33
Issue number5
DOIs
StatePublished - May 1 2003

Keywords

  • Antigen presentation
  • Human
  • MHC
  • T lymphocyte

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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