Major gene effect and additive familial pattern of inheritance of asthma exist among families of probands with sickle cell anemia and asthma

Keydra L. Phillips, Ping An, Jessica H. Boyd, Robert C. Strunk, James F Casella, Bruce A. Barton, Michael R. Debaun

Research output: Contribution to journalArticle

Abstract

In the United States, sickle cell anemia (SCA) affects approximately 1 in 400 African-American newborns. Acute episodes of pain and acute chest syndrome (ACS) are the two leading causes of hospitalization. A relationship between the diagnosis of asthma and the incidence of pain and ACS has been established. We tested the hypothesis that a familial pattern of inheritance of asthma exists among first degree relatives of probands with SCA and asthma. Segregation analysis was performed in 104 families ascertained through affected probands. Of these, 19.7% (41/208) of the parents and 31.8% (28/88) of siblings of affected probands reported having been told by a doctor he or she had asthma at any age. Modes of inheritance were tested, using the Pedigree Analysis Package parameterized for the discrete trait of asthma affection status. A major effect was present and significant. Further tests were performed to determine whether transmission probabilities of the major effect followed Mendelian expectations. The additive mode of inheritance was the most parsimonious, while the residual heritability was found negligible. Our results support the hypothesis that a familial pattern of inheritance of asthma exists among first degree relatives of probands with SCA and asthma, suggesting that asthma is a co-morbid condition with SCA rather than a lung disease phenotype mimicking asthma.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalAmerican Journal of Human Biology
Volume20
Issue number2
DOIs
StatePublished - Mar 2008

Fingerprint

sickle cell anemia
Inheritance Patterns
anemia
asthma
Sickle Cell Anemia
major genes
inheritance (genetics)
Asthma
gene
Genes
pain
Acute Chest Syndrome
sympathy
hospitalization
chest
segregation
parents
incidence
Disease
cause

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Anthropology

Cite this

Major gene effect and additive familial pattern of inheritance of asthma exist among families of probands with sickle cell anemia and asthma. / Phillips, Keydra L.; An, Ping; Boyd, Jessica H.; Strunk, Robert C.; Casella, James F; Barton, Bruce A.; Debaun, Michael R.

In: American Journal of Human Biology, Vol. 20, No. 2, 03.2008, p. 149-153.

Research output: Contribution to journalArticle

Phillips, Keydra L. ; An, Ping ; Boyd, Jessica H. ; Strunk, Robert C. ; Casella, James F ; Barton, Bruce A. ; Debaun, Michael R. / Major gene effect and additive familial pattern of inheritance of asthma exist among families of probands with sickle cell anemia and asthma. In: American Journal of Human Biology. 2008 ; Vol. 20, No. 2. pp. 149-153.
@article{c713d0a59ed14c6e93761bb4f2566fdb,
title = "Major gene effect and additive familial pattern of inheritance of asthma exist among families of probands with sickle cell anemia and asthma",
abstract = "In the United States, sickle cell anemia (SCA) affects approximately 1 in 400 African-American newborns. Acute episodes of pain and acute chest syndrome (ACS) are the two leading causes of hospitalization. A relationship between the diagnosis of asthma and the incidence of pain and ACS has been established. We tested the hypothesis that a familial pattern of inheritance of asthma exists among first degree relatives of probands with SCA and asthma. Segregation analysis was performed in 104 families ascertained through affected probands. Of these, 19.7{\%} (41/208) of the parents and 31.8{\%} (28/88) of siblings of affected probands reported having been told by a doctor he or she had asthma at any age. Modes of inheritance were tested, using the Pedigree Analysis Package parameterized for the discrete trait of asthma affection status. A major effect was present and significant. Further tests were performed to determine whether transmission probabilities of the major effect followed Mendelian expectations. The additive mode of inheritance was the most parsimonious, while the residual heritability was found negligible. Our results support the hypothesis that a familial pattern of inheritance of asthma exists among first degree relatives of probands with SCA and asthma, suggesting that asthma is a co-morbid condition with SCA rather than a lung disease phenotype mimicking asthma.",
author = "Phillips, {Keydra L.} and Ping An and Boyd, {Jessica H.} and Strunk, {Robert C.} and Casella, {James F} and Barton, {Bruce A.} and Debaun, {Michael R.}",
year = "2008",
month = "3",
doi = "10.1002/ajhb.20703",
language = "English (US)",
volume = "20",
pages = "149--153",
journal = "American Journal of Human Biology",
issn = "1042-0533",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Major gene effect and additive familial pattern of inheritance of asthma exist among families of probands with sickle cell anemia and asthma

AU - Phillips, Keydra L.

AU - An, Ping

AU - Boyd, Jessica H.

AU - Strunk, Robert C.

AU - Casella, James F

AU - Barton, Bruce A.

AU - Debaun, Michael R.

PY - 2008/3

Y1 - 2008/3

N2 - In the United States, sickle cell anemia (SCA) affects approximately 1 in 400 African-American newborns. Acute episodes of pain and acute chest syndrome (ACS) are the two leading causes of hospitalization. A relationship between the diagnosis of asthma and the incidence of pain and ACS has been established. We tested the hypothesis that a familial pattern of inheritance of asthma exists among first degree relatives of probands with SCA and asthma. Segregation analysis was performed in 104 families ascertained through affected probands. Of these, 19.7% (41/208) of the parents and 31.8% (28/88) of siblings of affected probands reported having been told by a doctor he or she had asthma at any age. Modes of inheritance were tested, using the Pedigree Analysis Package parameterized for the discrete trait of asthma affection status. A major effect was present and significant. Further tests were performed to determine whether transmission probabilities of the major effect followed Mendelian expectations. The additive mode of inheritance was the most parsimonious, while the residual heritability was found negligible. Our results support the hypothesis that a familial pattern of inheritance of asthma exists among first degree relatives of probands with SCA and asthma, suggesting that asthma is a co-morbid condition with SCA rather than a lung disease phenotype mimicking asthma.

AB - In the United States, sickle cell anemia (SCA) affects approximately 1 in 400 African-American newborns. Acute episodes of pain and acute chest syndrome (ACS) are the two leading causes of hospitalization. A relationship between the diagnosis of asthma and the incidence of pain and ACS has been established. We tested the hypothesis that a familial pattern of inheritance of asthma exists among first degree relatives of probands with SCA and asthma. Segregation analysis was performed in 104 families ascertained through affected probands. Of these, 19.7% (41/208) of the parents and 31.8% (28/88) of siblings of affected probands reported having been told by a doctor he or she had asthma at any age. Modes of inheritance were tested, using the Pedigree Analysis Package parameterized for the discrete trait of asthma affection status. A major effect was present and significant. Further tests were performed to determine whether transmission probabilities of the major effect followed Mendelian expectations. The additive mode of inheritance was the most parsimonious, while the residual heritability was found negligible. Our results support the hypothesis that a familial pattern of inheritance of asthma exists among first degree relatives of probands with SCA and asthma, suggesting that asthma is a co-morbid condition with SCA rather than a lung disease phenotype mimicking asthma.

UR - http://www.scopus.com/inward/record.url?scp=41149103976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41149103976&partnerID=8YFLogxK

U2 - 10.1002/ajhb.20703

DO - 10.1002/ajhb.20703

M3 - Article

C2 - 18161041

AN - SCOPUS:41149103976

VL - 20

SP - 149

EP - 153

JO - American Journal of Human Biology

JF - American Journal of Human Biology

SN - 1042-0533

IS - 2

ER -