Major depression in Down's syndrome

A. C. Warren, S. Holroyd, Marshal F. Folstein

Research output: Contribution to journalArticle

Abstract

Five patients with trisomy 21 (Down's syndrome (DS)), referred to us for evaluation of dementia, were instead found to have major depression. All had shown cognitive and behavioural deterioration and this had led to a mistaken diagnosis of Alzheimer's disease in two. We outline and contrast the features of major depression and Alzheimer's disease in DS, and suggest that electroconvulsive therapy is an effective treatment for major depression in DS.

Original languageEnglish (US)
Pages (from-to)202-205
Number of pages4
JournalBritish Journal of Psychiatry
Volume155
Issue numberAUG.
StatePublished - 1989

Fingerprint

Down Syndrome
Depression
Alzheimer Disease
Electroconvulsive Therapy
Dementia
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Warren, A. C., Holroyd, S., & Folstein, M. F. (1989). Major depression in Down's syndrome. British Journal of Psychiatry, 155(AUG.), 202-205.

Major depression in Down's syndrome. / Warren, A. C.; Holroyd, S.; Folstein, Marshal F.

In: British Journal of Psychiatry, Vol. 155, No. AUG., 1989, p. 202-205.

Research output: Contribution to journalArticle

Warren, AC, Holroyd, S & Folstein, MF 1989, 'Major depression in Down's syndrome', British Journal of Psychiatry, vol. 155, no. AUG., pp. 202-205.
Warren, A. C. ; Holroyd, S. ; Folstein, Marshal F. / Major depression in Down's syndrome. In: British Journal of Psychiatry. 1989 ; Vol. 155, No. AUG. pp. 202-205.
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