Maintenance of redox homeostasis by hypoxia-inducible factors

Debangshu Samanta; Gregg L. Semenza

doi:10.1016/j.redox.2017.05.022

Maintenance of redox homeostasis by hypoxia-inducible factors

Debangshu Samanta, Gregg L. Semenza

School of Medicine

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Oxidative phosphorylation enables cells to generate the large amounts of ATP required for development and maintenance of multicellular organisms. However, under conditions of reduced O₂ availability, electron transport becomes less efficient, leading to increased generation of superoxide anions. Hypoxia-inducible factors switch cells from oxidative to glycolytic metabolism, to reduce mitochondrial superoxide generation, and increase the synthesis of NADPH and glutathione, in order to maintain redox homeostasis under hypoxic conditions.

Original language	English (US)
Pages (from-to)	331-335
Number of pages	5
Journal	Redox Biology
Volume	13
DOIs	https://doi.org/10.1016/j.redox.2017.05.022
State	Published - Oct 2017

ASJC Scopus subject areas

Organic Chemistry
Clinical Biochemistry

Access to Document

10.1016/j.redox.2017.05.022

Cite this

@article{4fa64e958b054a9e8c3d7f498587df39,

title = "Maintenance of redox homeostasis by hypoxia-inducible factors",

abstract = "Oxidative phosphorylation enables cells to generate the large amounts of ATP required for development and maintenance of multicellular organisms. However, under conditions of reduced O2 availability, electron transport becomes less efficient, leading to increased generation of superoxide anions. Hypoxia-inducible factors switch cells from oxidative to glycolytic metabolism, to reduce mitochondrial superoxide generation, and increase the synthesis of NADPH and glutathione, in order to maintain redox homeostasis under hypoxic conditions.",

author = "Debangshu Samanta and Semenza, {Gregg L.}",

note = "Funding Information: Cancer research in the authors{\textquoteright} laboratory is supported in part by grants to G.L.S. from the American Cancer Society (122437-RP-12-090-01-COUN), Armstrong Family Foundation, Cindy Rosencrans Foundation, Department of Defense Breast Cancer Research Program (W81XWH-12-1-0464), and Emerson Collective Cancer Research Fund. G.L.S. is an American Cancer Society Research Professor and the C. Michael Armstrong Professor at the Johns Hopkins University School of Medicine. Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

month = oct,

doi = "10.1016/j.redox.2017.05.022",

language = "English (US)",

volume = "13",

pages = "331--335",

journal = "Redox Biology",

issn = "2213-2317",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Maintenance of redox homeostasis by hypoxia-inducible factors

AU - Samanta, Debangshu

AU - Semenza, Gregg L.

N1 - Funding Information: Cancer research in the authors’ laboratory is supported in part by grants to G.L.S. from the American Cancer Society (122437-RP-12-090-01-COUN), Armstrong Family Foundation, Cindy Rosencrans Foundation, Department of Defense Breast Cancer Research Program (W81XWH-12-1-0464), and Emerson Collective Cancer Research Fund. G.L.S. is an American Cancer Society Research Professor and the C. Michael Armstrong Professor at the Johns Hopkins University School of Medicine. Publisher Copyright: © 2017 The Authors

PY - 2017/10

Y1 - 2017/10

N2 - Oxidative phosphorylation enables cells to generate the large amounts of ATP required for development and maintenance of multicellular organisms. However, under conditions of reduced O2 availability, electron transport becomes less efficient, leading to increased generation of superoxide anions. Hypoxia-inducible factors switch cells from oxidative to glycolytic metabolism, to reduce mitochondrial superoxide generation, and increase the synthesis of NADPH and glutathione, in order to maintain redox homeostasis under hypoxic conditions.

AB - Oxidative phosphorylation enables cells to generate the large amounts of ATP required for development and maintenance of multicellular organisms. However, under conditions of reduced O2 availability, electron transport becomes less efficient, leading to increased generation of superoxide anions. Hypoxia-inducible factors switch cells from oxidative to glycolytic metabolism, to reduce mitochondrial superoxide generation, and increase the synthesis of NADPH and glutathione, in order to maintain redox homeostasis under hypoxic conditions.

UR - http://www.scopus.com/inward/record.url?scp=85020845318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020845318&partnerID=8YFLogxK

U2 - 10.1016/j.redox.2017.05.022

DO - 10.1016/j.redox.2017.05.022

M3 - Review article

C2 - 28624704

AN - SCOPUS:85020845318

SN - 2213-2317

VL - 13

SP - 331

EP - 335

JO - Redox Biology

JF - Redox Biology

ER -

Maintenance of redox homeostasis by hypoxia-inducible factors

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this