Maintenance of redox homeostasis by hypoxia-inducible factors

Research output: Contribution to journalReview article

Abstract

Oxidative phosphorylation enables cells to generate the large amounts of ATP required for development and maintenance of multicellular organisms. However, under conditions of reduced O2 availability, electron transport becomes less efficient, leading to increased generation of superoxide anions. Hypoxia-inducible factors switch cells from oxidative to glycolytic metabolism, to reduce mitochondrial superoxide generation, and increase the synthesis of NADPH and glutathione, in order to maintain redox homeostasis under hypoxic conditions.

Original languageEnglish (US)
Pages (from-to)331-335
Number of pages5
JournalRedox Biology
Volume13
DOIs
StatePublished - Oct 1 2017

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ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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