Maintenance of H1 Antagonists Self-Injection in Baboons

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14 Scopus citations


The ability of H1 histamine receptor antagonists to maintain self-injection in baboons using a cocaine substitution procedure was evaluated. Vehicle or a drug dose was substituted for cocaine (0.32 mg/kg/injection) for a period of 15 or more days. Tripelennamine (0.32 mg/kg/injection) and diphenhydramine (1.0 mg/kg/injection) maintained moderate-to-high rates of self-injection. Chlorpheniramine maintained low-to-moderate rates of self-injection. Promethazine did not reliably maintain self-injection, but rather, suppressed responding relative to control in 2 of 3 baboons (Papio cynocephalus). High doses of tripelennamine, diphenhydramine, and chlorpheniramine initially suppressed food intake and produced signs of behavioral toxicity, including agitation and sometimes seizures. These data demonstrate that H1 antagonists can serve as reinforcers and produce behavioral toxicity in the baboon.

Original languageEnglish (US)
Pages (from-to)26-32
Number of pages7
JournalExperimental and clinical psychopharmacology
Issue number1
StatePublished - Feb 1995

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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