TY - JOUR
T1 - Maintenance of H1 Antagonists Self-Injection in Baboons
AU - Sannerud, Christine A.
AU - Kaminski, Barbara J.
AU - Griffiths, Roland R.
PY - 1995/2
Y1 - 1995/2
N2 - The ability of H1 histamine receptor antagonists to maintain self-injection in baboons using a cocaine substitution procedure was evaluated. Vehicle or a drug dose was substituted for cocaine (0.32 mg/kg/injection) for a period of 15 or more days. Tripelennamine (0.32 mg/kg/injection) and diphenhydramine (1.0 mg/kg/injection) maintained moderate-to-high rates of self-injection. Chlorpheniramine maintained low-to-moderate rates of self-injection. Promethazine did not reliably maintain self-injection, but rather, suppressed responding relative to control in 2 of 3 baboons (Papio cynocephalus). High doses of tripelennamine, diphenhydramine, and chlorpheniramine initially suppressed food intake and produced signs of behavioral toxicity, including agitation and sometimes seizures. These data demonstrate that H1 antagonists can serve as reinforcers and produce behavioral toxicity in the baboon.
AB - The ability of H1 histamine receptor antagonists to maintain self-injection in baboons using a cocaine substitution procedure was evaluated. Vehicle or a drug dose was substituted for cocaine (0.32 mg/kg/injection) for a period of 15 or more days. Tripelennamine (0.32 mg/kg/injection) and diphenhydramine (1.0 mg/kg/injection) maintained moderate-to-high rates of self-injection. Chlorpheniramine maintained low-to-moderate rates of self-injection. Promethazine did not reliably maintain self-injection, but rather, suppressed responding relative to control in 2 of 3 baboons (Papio cynocephalus). High doses of tripelennamine, diphenhydramine, and chlorpheniramine initially suppressed food intake and produced signs of behavioral toxicity, including agitation and sometimes seizures. These data demonstrate that H1 antagonists can serve as reinforcers and produce behavioral toxicity in the baboon.
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U2 - 10.1037/1064-1297.3.1.26
DO - 10.1037/1064-1297.3.1.26
M3 - Article
AN - SCOPUS:0028943923
SN - 1064-1297
VL - 3
SP - 26
EP - 32
JO - Experimental and clinical psychopharmacology
JF - Experimental and clinical psychopharmacology
IS - 1
ER -