In the immunotherapy of hay fever with pollen extracts, when treatment is temporarily discontinued after a course of weekly injections, the decline of blocking antibodies as measured by inhibition of leukocyte histamine release takes many months. The practice of giving booster injections in perennial immunotherapy every 2 or 3 weeks therefore appears unnecessary. To test this hypothesis, a schedule of perennial treatment with boosters at 6 week intervals was tried in a group of ragweed hay fever patients who had previously been treated with preseasonal injections for 2 or more years. Over two years, 8 injections a year (omitting an injection during the season) maintained and perhaps even augmented both clinical improvement and blocking antibody levels without problems caused by untoward reactions.
ASJC Scopus subject areas
- Immunology and Allergy