Magnitude and duration of antitoxic response to human infection with vibrio cholerae

Nathaniel F. Pierce; John G. Banwell; R. Bradley Sack; Rupak C. Mitra; Arabindo Mondal

doi:10.1093/infdis/121.Supplement.S31

Magnitude and duration of antitoxic response to human infection with vibrio cholerae

Nathaniel F. Pierce, John G. Banwell, R. Bradley Sack, Rupak C. Mitra, Arabindo Mondal

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The circulating antitoxic and antipermeability factor response in patients convalescing from cholera is variable and frequently of small magnitude. The peak titer of these antibodies is diminished by prompt treatment with tetracycline. The antitoxic titer in convalescent patients remains significantly elevated for at least 12-18 months. Repeated parenteral immunization of rabbits with a purified cholera exotoxin produces antitoxic titers exceeding those in convalescent patients by 10- to 100-fold, or more. The titers of antitoxin and antipermeability factor were similar under all conditions, a fact suggesting their identity, but neither was directly related to vibriocidal antibody.

Original language	English (US)
Pages (from-to)	S31-S35
Journal	Journal of Infectious Diseases
Volume	121
DOIs	https://doi.org/10.1093/infdis/121.Supplement.S31
State	Published - May 1970
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/121.Supplement.S31

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title = "Magnitude and duration of antitoxic response to human infection with vibrio cholerae",

abstract = "The circulating antitoxic and antipermeability factor response in patients convalescing from cholera is variable and frequently of small magnitude. The peak titer of these antibodies is diminished by prompt treatment with tetracycline. The antitoxic titer in convalescent patients remains significantly elevated for at least 12-18 months. Repeated parenteral immunization of rabbits with a purified cholera exotoxin produces antitoxic titers exceeding those in convalescent patients by 10- to 100-fold, or more. The titers of antitoxin and antipermeability factor were similar under all conditions, a fact suggesting their identity, but neither was directly related to vibriocidal antibody.",

author = "Pierce, {Nathaniel F.} and Banwell, {John G.} and Sack, {R. Bradley} and Mitra, {Rupak C.} and Arabindo Mondal",

note = "Funding Information: This work was supported in part by research grants AI-07628-02 and 5R07TW00141-08 CIC, U.S. Public Health Service, Washington, D.C.; and by funding under Public Law 480, Section 104(c), Agreement 5X4317.",

year = "1970",

month = may,

doi = "10.1093/infdis/121.Supplement.S31",

language = "English (US)",

volume = "121",

pages = "S31--S35",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

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T1 - Magnitude and duration of antitoxic response to human infection with vibrio cholerae

AU - Pierce, Nathaniel F.

AU - Banwell, John G.

AU - Sack, R. Bradley

AU - Mitra, Rupak C.

AU - Mondal, Arabindo

N1 - Funding Information: This work was supported in part by research grants AI-07628-02 and 5R07TW00141-08 CIC, U.S. Public Health Service, Washington, D.C.; and by funding under Public Law 480, Section 104(c), Agreement 5X4317.

PY - 1970/5

Y1 - 1970/5

N2 - The circulating antitoxic and antipermeability factor response in patients convalescing from cholera is variable and frequently of small magnitude. The peak titer of these antibodies is diminished by prompt treatment with tetracycline. The antitoxic titer in convalescent patients remains significantly elevated for at least 12-18 months. Repeated parenteral immunization of rabbits with a purified cholera exotoxin produces antitoxic titers exceeding those in convalescent patients by 10- to 100-fold, or more. The titers of antitoxin and antipermeability factor were similar under all conditions, a fact suggesting their identity, but neither was directly related to vibriocidal antibody.

AB - The circulating antitoxic and antipermeability factor response in patients convalescing from cholera is variable and frequently of small magnitude. The peak titer of these antibodies is diminished by prompt treatment with tetracycline. The antitoxic titer in convalescent patients remains significantly elevated for at least 12-18 months. Repeated parenteral immunization of rabbits with a purified cholera exotoxin produces antitoxic titers exceeding those in convalescent patients by 10- to 100-fold, or more. The titers of antitoxin and antipermeability factor were similar under all conditions, a fact suggesting their identity, but neither was directly related to vibriocidal antibody.

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Magnitude and duration of antitoxic response to human infection with vibrio cholerae

Abstract

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