Magnitude and duration of antitoxic response to human infection with vibrio cholerae

Nathaniel F. Pierce, John G. Banwell, R. Bradley Sack, Rupak C. Mitra, Arabindo Mondal

Research output: Contribution to journalArticle


The circulating antitoxic and antipermeability factor response in patients convalescing from cholera is variable and frequently of small magnitude. The peak titer of these antibodies is diminished by prompt treatment with tetracycline. The antitoxic titer in convalescent patients remains significantly elevated for at least 12-18 months. Repeated parenteral immunization of rabbits with a purified cholera exotoxin produces antitoxic titers exceeding those in convalescent patients by 10- to 100-fold, or more. The titers of antitoxin and antipermeability factor were similar under all conditions, a fact suggesting their identity, but neither was directly related to vibriocidal antibody.

Original languageEnglish (US)
Pages (from-to)S31-S35
JournalJournal of Infectious Diseases
Publication statusPublished - 1970
Externally publishedYes


ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

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