Magnetosonoporation: Instant magnetic labeling of stem cells

Bensheng Qiu; Daohai Xie; Piotr Walczak; Xubin Li; Jesus Ruiz-Cabello; Satoshi Minoshima; Jeff W.M. Bulte; Xiaoming Yang

doi:10.1002/mrm.22348

Magnetosonoporation: Instant magnetic labeling of stem cells

Bensheng Qiu, Daohai Xie, Piotr Walczak, Xubin Li, Jesus Ruiz-Cabello, Satoshi Minoshima, Jeff W.M. Bulte, Xiaoming Yang

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The purpose of this study was to develop an instant MR cell labeling technique, called magnetosonoporation. First, a magnetosonoporation apparatus was successfully established for MR labeling of stem cells. Then, the safety of this new cell labeling approach was confirmed by evaluation of cell viability, proliferation, and differentiation of magnetosonoporation-labeled and unlabeled C17.2 neural stem cells. Subsequently, the feasibility of using in vivo MRI to detect magnetosonoporation/Feridex-labeled stem cells was validated in living animals and confirmed by histologic correlation. The magnetosonoporation technique is expected to be convenient, efficient, and safe for future clinical application of MRI-guided cell therapies.

Original language	English (US)
Pages (from-to)	1437-1441
Number of pages	5
Journal	Magnetic resonance in medicine
Volume	63
Issue number	6
DOIs	https://doi.org/10.1002/mrm.22348
State	Published - Jun 2010
Externally published	Yes

Keywords

MR cell labeling
MRI
Magnetosonoporation
Stem cells
Superparamagnetic iron oxide particles

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/mrm.22348

Cite this

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abstract = "The purpose of this study was to develop an instant MR cell labeling technique, called magnetosonoporation. First, a magnetosonoporation apparatus was successfully established for MR labeling of stem cells. Then, the safety of this new cell labeling approach was confirmed by evaluation of cell viability, proliferation, and differentiation of magnetosonoporation-labeled and unlabeled C17.2 neural stem cells. Subsequently, the feasibility of using in vivo MRI to detect magnetosonoporation/Feridex-labeled stem cells was validated in living animals and confirmed by histologic correlation. The magnetosonoporation technique is expected to be convenient, efficient, and safe for future clinical application of MRI-guided cell therapies.",

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AU - Qiu, Bensheng

AU - Xie, Daohai

AU - Walczak, Piotr

AU - Li, Xubin

AU - Ruiz-Cabello, Jesus

AU - Minoshima, Satoshi

AU - Bulte, Jeff W.M.

AU - Yang, Xiaoming

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Magnetosonoporation: Instant magnetic labeling of stem cells

Abstract

Keywords

ASJC Scopus subject areas

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