Magnetoencephalographic and functional MRI connectomics in schizophrenia via intra- and inter-network connectivity

Jon M. Houck, Mustafa S. Çetin, Juan R. Bustillo, Cheryl Aine, Jose Cañive, Nora Perrone-Bizzozero, Robert J. Thoma, Jon M. Houck, Mustafa S. Çetin, Andrew R. Mayer, Julia Stephen, Cheryl Aine, Vince Daniel Calhoun, Juan R. Bustillo, Jose Cañive, Robert J. Thoma, Matthew J. Brookes, Cheryl Aine, Matthew J. Brookes, Mustafa S. ÇetinNora Perrone-Bizzozero

Research output: Contribution to journalArticle

Abstract

Examination of intrinsic functional connectivity using functional MRI (fMRI) has provided important findings regarding dysconnectivity in schizophrenia. Extending these results using a complementary neuroimaging modality, magnetoencephalography (MEG), we present the first direct comparison of functional connectivity between schizophrenia patients and controls, using these two modalities combined. We developed a novel MEG approach for estimation of networks using MEG that incorporates spatial independent component analysis (ICA) and pairwise correlations between independent component timecourses, to estimate intra- and intern-network connectivity. This analysis enables group-level inference and testing of between-group differences. Resting state MEG and fMRI data were acquired from a large sample of healthy controls (n=45) and schizophrenia patients (n=46). Group spatial ICA was performed on fMRI and MEG data to extract intrinsic fMRI and MEG networks and to compensate for signal leakage in MEG. Similar, but not identical spatial independent components were detected for MEG and fMRI. Analysis of functional network connectivity (FNC; i.e., pairwise correlations in network (ICA component) timecourses) revealed a differential between-modalities pattern, with greater connectivity among occipital networks in fMRI and among frontal networks in MEG. Most importantly, significant differences between controls and patients were observed in both modalities. MEG FNC results in particular indicated dysfunctional hyperconnectivity within frontal and temporal networks in patients, while in fMRI FNC was always greater for controls than for patients. This is the first study to apply group spatial ICA as an approach to leakage correction, and as such our results may be biased by spatial leakage effects. Results suggest that combining these two neuroimaging modalities reveals additional disease-relevant patterns of connectivity that were not detectable with fMRI or MEG alone.

Original languageEnglish (US)
Pages (from-to)96-106
Number of pages11
JournalNeuroImage
Volume145
DOIs
StatePublished - Jan 15 2017
Externally publishedYes

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Connectome
Magnetoencephalography
Schizophrenia
Magnetic Resonance Imaging
Neuroimaging

Keywords

  • Functional connectivity
  • Imaging
  • MEG
  • Resting state connectivity
  • Schizophrenia

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Houck, J. M., Çetin, M. S., Bustillo, J. R., Aine, C., Cañive, J., Perrone-Bizzozero, N., ... Perrone-Bizzozero, N. (2017). Magnetoencephalographic and functional MRI connectomics in schizophrenia via intra- and inter-network connectivity. NeuroImage, 145, 96-106. https://doi.org/10.1016/j.neuroimage.2016.10.011

Magnetoencephalographic and functional MRI connectomics in schizophrenia via intra- and inter-network connectivity. / Houck, Jon M.; Çetin, Mustafa S.; Bustillo, Juan R.; Aine, Cheryl; Cañive, Jose; Perrone-Bizzozero, Nora; Thoma, Robert J.; Houck, Jon M.; Çetin, Mustafa S.; Mayer, Andrew R.; Stephen, Julia; Aine, Cheryl; Calhoun, Vince Daniel; Bustillo, Juan R.; Cañive, Jose; Thoma, Robert J.; Brookes, Matthew J.; Aine, Cheryl; Brookes, Matthew J.; Çetin, Mustafa S.; Perrone-Bizzozero, Nora.

In: NeuroImage, Vol. 145, 15.01.2017, p. 96-106.

Research output: Contribution to journalArticle

Houck, JM, Çetin, MS, Bustillo, JR, Aine, C, Cañive, J, Perrone-Bizzozero, N, Thoma, RJ, Houck, JM, Çetin, MS, Mayer, AR, Stephen, J, Aine, C, Calhoun, VD, Bustillo, JR, Cañive, J, Thoma, RJ, Brookes, MJ, Aine, C, Brookes, MJ, Çetin, MS & Perrone-Bizzozero, N 2017, 'Magnetoencephalographic and functional MRI connectomics in schizophrenia via intra- and inter-network connectivity', NeuroImage, vol. 145, pp. 96-106. https://doi.org/10.1016/j.neuroimage.2016.10.011
Houck, Jon M. ; Çetin, Mustafa S. ; Bustillo, Juan R. ; Aine, Cheryl ; Cañive, Jose ; Perrone-Bizzozero, Nora ; Thoma, Robert J. ; Houck, Jon M. ; Çetin, Mustafa S. ; Mayer, Andrew R. ; Stephen, Julia ; Aine, Cheryl ; Calhoun, Vince Daniel ; Bustillo, Juan R. ; Cañive, Jose ; Thoma, Robert J. ; Brookes, Matthew J. ; Aine, Cheryl ; Brookes, Matthew J. ; Çetin, Mustafa S. ; Perrone-Bizzozero, Nora. / Magnetoencephalographic and functional MRI connectomics in schizophrenia via intra- and inter-network connectivity. In: NeuroImage. 2017 ; Vol. 145. pp. 96-106.
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