Magnetization transfer and adiabatic T1 MRI reveal abnormalities in normal-appearing white matter of subjects with multiple sclerosis

Silvia Mangia, Adam F. Carpenter, Andy E. Tyan, Lynn E. Eberly, Michael Garwood, Shalom Michaeli

Research output: Contribution to journalArticle

Abstract

Background: Diffuse abnormalities are known to occur within the brain tissue of multiple sclerosis (MS) patients thatis normal appearing on T1-weighted and T2-weighted magnetic resonance images.Objectives: With the goal of exploring the sensitivity of novel MRI parameters to detect such abnormalities, weimplemented an inversion-prepared magnetization transfer (MT) protocol and adiabatic T1ρ and T2ρrotating framerelaxation methods.Methods: Nine relapsing-remitting MS patients and seven healthy controls were recruited. Relaxation parameters weremeasured in a single slice just above the lateral ventricles and approximately parallel to the AC-PC line.Results: The MT ratio of regions encompassing the normal-appearing white matter (NAWM) was different in MSpatients as compared with controls (p = 0.043); however, the T1 measured during off-resonance irradiation (T1sat) wassubstantially more sensitive than the MT ratio for detecting differences between groups (p = 0.0006). Adiabatic T1ρwassignificantly prolonged in the NAWM of MS patents as compared to controls (by 6%, p = 0.026), while no differenceswere found among groups for T2ρ. No differences among groups were observed in the cortical gray matter for anyrelaxation parameter.Conclusions: The results suggest degenerative processes occurring in the NAWM of MS, likely not accompanied bysignificant abnormalities in iron content.

Original languageEnglish (US)
Pages (from-to)1066-1073
Number of pages8
JournalMultiple Sclerosis Journal
Volume20
Issue number8
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Multiple Sclerosis
Relapsing-Remitting Multiple Sclerosis
Patents
Lateral Ventricles
Magnetic Resonance Spectroscopy
Iron
Brain
White Matter
Gray Matter

Keywords

  • adiabatic pulses
  • inversion-prepared MT
  • MRI
  • multiple sclerosis
  • relapsing-remitting
  • rotating frame relaxation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Magnetization transfer and adiabatic T1 MRI reveal abnormalities in normal-appearing white matter of subjects with multiple sclerosis. / Mangia, Silvia; Carpenter, Adam F.; Tyan, Andy E.; Eberly, Lynn E.; Garwood, Michael; Michaeli, Shalom.

In: Multiple Sclerosis Journal, Vol. 20, No. 8, 01.01.2014, p. 1066-1073.

Research output: Contribution to journalArticle

Mangia, Silvia ; Carpenter, Adam F. ; Tyan, Andy E. ; Eberly, Lynn E. ; Garwood, Michael ; Michaeli, Shalom. / Magnetization transfer and adiabatic T1 MRI reveal abnormalities in normal-appearing white matter of subjects with multiple sclerosis. In: Multiple Sclerosis Journal. 2014 ; Vol. 20, No. 8. pp. 1066-1073.
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AU - Garwood, Michael

AU - Michaeli, Shalom

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