Magnetization transfer and adiabatic R MRI in the brainstem of Parkinson's disease

Paul J. Tuite, Silvia Mangia, Andrew E. Tyan, Michael K. Lee, Michael Garwood, Shalom Michaeli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In addition to classic midbrain pathology, Parkinson's disease (PD) is accompanied by changes in pontine and medullary brainstem structures. These additional abnormalities may underlie non-motor features as well as play a role in motor disability. Methods: Using novel magnetic resonance imaging (MRI) methods based on rotating frame adiabatic R (i.e., measurements of longitudinal relaxation during adiabatic full passage pulses) and modified magnetization transfer (MT) MRI mapping, we sought to identify brainstem alterations in nine individuals with mild-moderate PD (off medication) and ten age-matched controls at 4 T. Results: We discovered significant differences in MRI parameters between midbrain and medullary brainstem structures in control subjects as compared to PD patients. Conclusions: These findings support the presence of underlying functional/structural brainstem changes in mild-moderate PD.

Original languageEnglish (US)
Pages (from-to)623-625
Number of pages3
JournalParkinsonism and Related Disorders
Volume18
Issue number5
DOIs
StatePublished - Jun 2012

Keywords

  • MRI
  • Magnetization transfer
  • Medulla
  • Parkinson's disease
  • R1ρ

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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