Magnetic resonance techniques to monitor the long term evolution of multiple sclerosis pathology and to monitor definitive clinical trials

D. W. Paty, H. McFarland

Research output: Contribution to journalArticle

Abstract

Magnetic resonance has provided a literal window on the brain to visualise the actual pathology of MS as it evolves in the living patient. Natural history studies disclosed that MRI visualised pathological activity was seen at 5 to 10 x the rate of clinical relapses. Utilising that knowledge, systematic MRI monitoring has been used to supplement clinical monitoring to show the treatment effect in several clinical trials. This chapter explains how MR techniques can be used to further explore the evolution of in vivo pathology both in clinical trials and natural history studies.

Original languageEnglish (US)
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume64
Issue numberSUPPL. 1
StatePublished - May 1998
Externally publishedYes

Fingerprint

Natural History
Multiple Sclerosis
Magnetic Resonance Spectroscopy
Clinical Trials
Pathology
Recurrence
Brain
Therapeutics

Keywords

  • Axonal loss
  • Clinical trials
  • Magnetic resonance imaging
  • Multiple sclerosis evolution

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

@article{ba1d4d6701cc46c5be0114b95f447ba0,
title = "Magnetic resonance techniques to monitor the long term evolution of multiple sclerosis pathology and to monitor definitive clinical trials",
abstract = "Magnetic resonance has provided a literal window on the brain to visualise the actual pathology of MS as it evolves in the living patient. Natural history studies disclosed that MRI visualised pathological activity was seen at 5 to 10 x the rate of clinical relapses. Utilising that knowledge, systematic MRI monitoring has been used to supplement clinical monitoring to show the treatment effect in several clinical trials. This chapter explains how MR techniques can be used to further explore the evolution of in vivo pathology both in clinical trials and natural history studies.",
keywords = "Axonal loss, Clinical trials, Magnetic resonance imaging, Multiple sclerosis evolution",
author = "Paty, {D. W.} and H. McFarland",
year = "1998",
month = "5",
language = "English (US)",
volume = "64",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Magnetic resonance techniques to monitor the long term evolution of multiple sclerosis pathology and to monitor definitive clinical trials

AU - Paty, D. W.

AU - McFarland, H.

PY - 1998/5

Y1 - 1998/5

N2 - Magnetic resonance has provided a literal window on the brain to visualise the actual pathology of MS as it evolves in the living patient. Natural history studies disclosed that MRI visualised pathological activity was seen at 5 to 10 x the rate of clinical relapses. Utilising that knowledge, systematic MRI monitoring has been used to supplement clinical monitoring to show the treatment effect in several clinical trials. This chapter explains how MR techniques can be used to further explore the evolution of in vivo pathology both in clinical trials and natural history studies.

AB - Magnetic resonance has provided a literal window on the brain to visualise the actual pathology of MS as it evolves in the living patient. Natural history studies disclosed that MRI visualised pathological activity was seen at 5 to 10 x the rate of clinical relapses. Utilising that knowledge, systematic MRI monitoring has been used to supplement clinical monitoring to show the treatment effect in several clinical trials. This chapter explains how MR techniques can be used to further explore the evolution of in vivo pathology both in clinical trials and natural history studies.

KW - Axonal loss

KW - Clinical trials

KW - Magnetic resonance imaging

KW - Multiple sclerosis evolution

UR - http://www.scopus.com/inward/record.url?scp=0031779731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031779731&partnerID=8YFLogxK

M3 - Article

C2 - 9647285

AN - SCOPUS:0031779731

VL - 64

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - SUPPL. 1

ER -