Magnetic resonance techniques to monitor the long term evolution of multiple sclerosis pathology and to monitor definitive clinical trials

D. W. Paty, H. McFarland

Research output: Contribution to journalArticle

Abstract

Magnetic resonance has provided a literal window on the brain to visualise the actual pathology of MS as it evolves in the living patient. Natural history studies disclosed that MRI visualised pathological activity was seen at 5 to 10 x the rate of clinical relapses. Utilising that knowledge, systematic MRI monitoring has been used to supplement clinical monitoring to show the treatment effect in several clinical trials. This chapter explains how MR techniques can be used to further explore the evolution of in vivo pathology both in clinical trials and natural history studies.

Original languageEnglish (US)
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume64
Issue numberSUPPL. 1
StatePublished - May 1998
Externally publishedYes

Keywords

  • Axonal loss
  • Clinical trials
  • Magnetic resonance imaging
  • Multiple sclerosis evolution

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

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