Magnetic resonance stress tagging in ischemic heart disease

Ingo Paetsch, Daniela Föll, Adam Kaluza, Roger Luechinger, Matthias Stuber, Axel Bornstedt, Andreas Wahl, Eckart Fleck, Eike Nagel

Research output: Contribution to journalArticle

Abstract

High-dose dobutamine magnetic resonance stress testing has been shown to be superior to dobutamine stress echocardiography for diagnosis of coronary artery disease (CAD). We determined the feasibility of quantitative myocardial tagging during low- and high-dose dobutamine stress and tested the ability of global systolic and diastolic quantitative parameters to identify patients with significant CAD. Twenty-five patients suspected of having significant CAD were examined with a standard high-dose dobutamine/atropine stress magnetic resonance protocol (1.5-T scanner, Philips). All patients underwent invasive coronary angiography as the standard of reference for the presence (n = 13) or absence (n = 12) of significant CAD. During low-dose dobutamine stress, systolic (circumferential shortening, systolic rotation, and systolic rotation velocity) and diastolic (velocity of circumferential lengthening and diastolic rotation velocity) parameters changed significantly in patients without CAD (all P <0.05 vs. rest) but not in patients with CAD. Identification of patients without and with CAD during low-dose stress was possible using the diastolic parameter of "time to peak untwist." At high-dose stress, none of the global systolic or diastolic parameters showed the potential to identify the presence of significant CAD. With myocardial tagging, a quantitative analysis of systolic and diastolic function was feasible during low- and high-dose dobutamine stress. In our study, the diastolic parameter of time to peak untwist as assessed during low-dose dobutamine stress was the most promising global parameter for identification of patients with significant CAD. Thus quantitative myocardial tagging may become a tool that reduces the need for high-dose dobutamine stress.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume288
Issue number6 57-6
DOIs
StatePublished - Jun 2005

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Dobutamine
Myocardial Ischemia
Coronary Artery Disease
Magnetic Resonance Spectroscopy
Stress Echocardiography
Coronary Angiography
Atropine

Keywords

  • Diastolic rotation velocity
  • Dobutamine
  • Echocardiography
  • Systolic rotation velocity
  • Time to peak untwist

ASJC Scopus subject areas

  • Physiology

Cite this

Paetsch, I., Föll, D., Kaluza, A., Luechinger, R., Stuber, M., Bornstedt, A., ... Nagel, E. (2005). Magnetic resonance stress tagging in ischemic heart disease. American Journal of Physiology - Heart and Circulatory Physiology, 288(6 57-6). https://doi.org/10.1152/ajpheart.01017.2003

Magnetic resonance stress tagging in ischemic heart disease. / Paetsch, Ingo; Föll, Daniela; Kaluza, Adam; Luechinger, Roger; Stuber, Matthias; Bornstedt, Axel; Wahl, Andreas; Fleck, Eckart; Nagel, Eike.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 288, No. 6 57-6, 06.2005.

Research output: Contribution to journalArticle

Paetsch, I, Föll, D, Kaluza, A, Luechinger, R, Stuber, M, Bornstedt, A, Wahl, A, Fleck, E & Nagel, E 2005, 'Magnetic resonance stress tagging in ischemic heart disease', American Journal of Physiology - Heart and Circulatory Physiology, vol. 288, no. 6 57-6. https://doi.org/10.1152/ajpheart.01017.2003
Paetsch, Ingo ; Föll, Daniela ; Kaluza, Adam ; Luechinger, Roger ; Stuber, Matthias ; Bornstedt, Axel ; Wahl, Andreas ; Fleck, Eckart ; Nagel, Eike. / Magnetic resonance stress tagging in ischemic heart disease. In: American Journal of Physiology - Heart and Circulatory Physiology. 2005 ; Vol. 288, No. 6 57-6.
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