Magnetic resonance spin-labeling perfusion imaging of synovitis in inflammatory arthritis at 3.0 T

Andreas Boss, Petros Martirosian, Jan Fritz, Ina Kötter, Jörg C. Henes, Claus D. Claussen, Fritz Schick, Marius Horger

Research output: Contribution to journalArticle

Abstract

Objective: The aim of this study was to test the feasibility of arterial spin labeling (ASL) perfusion imaging of synovitis in inflammatory joint diseases on a clinical 3.0 T whole-body scanner. Materials and methods: Fifteen patients (geometric mean 47 years, range 8-69 years) with different types of inflammatory arthritis of the finger or wrist joints participated in the study. In addition to conventional spin-echo and dynamic contrast-enhanced FLASH3D sequences, a novel spin-labeling technique (FAIR-TrueFISP) for quantitative assessment of tissue perfusion was applied. Perfusion maps were calculated pixel-wise by means of the extended Bloch equations. Results: Perfusion maps showed good image quality with clear visualization of hyperaemia in synovitis. The computed perfusion maps corresponded best to subtraction images of the dynamic series from 30 to 60 s after contrast-medium injection. The quantitative perfusion values of synovitis showed a good correlation with the disease activity. Perfusion values for inflamed synovium in phase of high activity were up to 230 ml/100 g tissue/min. Conclusion: The proposed modality allows for the assessment of disease activity in arthritis without the application of contrast-medium offering a new tool for therapy monitoring. As the technique provides quantitative information on hyperaemia, it potentially offers new insights in the pathophysiology of arthritic diseases.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalMagma (New York, N.Y.)
Volume22
Issue number3
DOIs
StatePublished - Jun 2009
Externally publishedYes

Fingerprint

Perfusion Imaging
Synovitis
Arthritis
Magnetic Resonance Spectroscopy
Perfusion
Hyperemia
Contrast Media
Finger Joint
Wrist Joint
Synovial Membrane
Joint Diseases
Injections

Keywords

  • Arterial spin labeling
  • ASL
  • Inflammatory joint diseases
  • Perfusion imaging
  • Synovitis

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Magnetic resonance spin-labeling perfusion imaging of synovitis in inflammatory arthritis at 3.0 T. / Boss, Andreas; Martirosian, Petros; Fritz, Jan; Kötter, Ina; Henes, Jörg C.; Claussen, Claus D.; Schick, Fritz; Horger, Marius.

In: Magma (New York, N.Y.), Vol. 22, No. 3, 06.2009, p. 175-180.

Research output: Contribution to journalArticle

Boss, A, Martirosian, P, Fritz, J, Kötter, I, Henes, JC, Claussen, CD, Schick, F & Horger, M 2009, 'Magnetic resonance spin-labeling perfusion imaging of synovitis in inflammatory arthritis at 3.0 T', Magma (New York, N.Y.), vol. 22, no. 3, pp. 175-180. https://doi.org/10.1007/s10334-008-0162-y
Boss, Andreas ; Martirosian, Petros ; Fritz, Jan ; Kötter, Ina ; Henes, Jörg C. ; Claussen, Claus D. ; Schick, Fritz ; Horger, Marius. / Magnetic resonance spin-labeling perfusion imaging of synovitis in inflammatory arthritis at 3.0 T. In: Magma (New York, N.Y.). 2009 ; Vol. 22, No. 3. pp. 175-180.
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