Abstract
Objective: The aim of this study was to test the feasibility of arterial spin labeling (ASL) perfusion imaging of synovitis in inflammatory joint diseases on a clinical 3.0 T whole-body scanner. Materials and methods: Fifteen patients (geometric mean 47 years, range 8-69 years) with different types of inflammatory arthritis of the finger or wrist joints participated in the study. In addition to conventional spin-echo and dynamic contrast-enhanced FLASH3D sequences, a novel spin-labeling technique (FAIR-TrueFISP) for quantitative assessment of tissue perfusion was applied. Perfusion maps were calculated pixel-wise by means of the extended Bloch equations. Results: Perfusion maps showed good image quality with clear visualization of hyperaemia in synovitis. The computed perfusion maps corresponded best to subtraction images of the dynamic series from 30 to 60 s after contrast-medium injection. The quantitative perfusion values of synovitis showed a good correlation with the disease activity. Perfusion values for inflamed synovium in phase of high activity were up to 230 ml/100 g tissue/min. Conclusion: The proposed modality allows for the assessment of disease activity in arthritis without the application of contrast-medium offering a new tool for therapy monitoring. As the technique provides quantitative information on hyperaemia, it potentially offers new insights in the pathophysiology of arthritic diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 175-180 |
| Number of pages | 6 |
| Journal | Magma (New York, N.Y.) |
| Volume | 22 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2009 |
| Externally published | Yes |
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Keywords
- Arterial spin labeling
- ASL
- Inflammatory joint diseases
- Perfusion imaging
- Synovitis
ASJC Scopus subject areas
- Biophysics
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Magnetic resonance spin-labeling perfusion imaging of synovitis in inflammatory arthritis at 3.0 T. / Boss, Andreas; Martirosian, Petros; Fritz, Jan; Kötter, Ina; Henes, Jörg C.; Claussen, Claus D.; Schick, Fritz; Horger, Marius.
In: Magma (New York, N.Y.), Vol. 22, No. 3, 06.2009, p. 175-180.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Magnetic resonance spin-labeling perfusion imaging of synovitis in inflammatory arthritis at 3.0 T
AU - Boss, Andreas
AU - Martirosian, Petros
AU - Fritz, Jan
AU - Kötter, Ina
AU - Henes, Jörg C.
AU - Claussen, Claus D.
AU - Schick, Fritz
AU - Horger, Marius
PY - 2009/6
Y1 - 2009/6
N2 - Objective: The aim of this study was to test the feasibility of arterial spin labeling (ASL) perfusion imaging of synovitis in inflammatory joint diseases on a clinical 3.0 T whole-body scanner. Materials and methods: Fifteen patients (geometric mean 47 years, range 8-69 years) with different types of inflammatory arthritis of the finger or wrist joints participated in the study. In addition to conventional spin-echo and dynamic contrast-enhanced FLASH3D sequences, a novel spin-labeling technique (FAIR-TrueFISP) for quantitative assessment of tissue perfusion was applied. Perfusion maps were calculated pixel-wise by means of the extended Bloch equations. Results: Perfusion maps showed good image quality with clear visualization of hyperaemia in synovitis. The computed perfusion maps corresponded best to subtraction images of the dynamic series from 30 to 60 s after contrast-medium injection. The quantitative perfusion values of synovitis showed a good correlation with the disease activity. Perfusion values for inflamed synovium in phase of high activity were up to 230 ml/100 g tissue/min. Conclusion: The proposed modality allows for the assessment of disease activity in arthritis without the application of contrast-medium offering a new tool for therapy monitoring. As the technique provides quantitative information on hyperaemia, it potentially offers new insights in the pathophysiology of arthritic diseases.
AB - Objective: The aim of this study was to test the feasibility of arterial spin labeling (ASL) perfusion imaging of synovitis in inflammatory joint diseases on a clinical 3.0 T whole-body scanner. Materials and methods: Fifteen patients (geometric mean 47 years, range 8-69 years) with different types of inflammatory arthritis of the finger or wrist joints participated in the study. In addition to conventional spin-echo and dynamic contrast-enhanced FLASH3D sequences, a novel spin-labeling technique (FAIR-TrueFISP) for quantitative assessment of tissue perfusion was applied. Perfusion maps were calculated pixel-wise by means of the extended Bloch equations. Results: Perfusion maps showed good image quality with clear visualization of hyperaemia in synovitis. The computed perfusion maps corresponded best to subtraction images of the dynamic series from 30 to 60 s after contrast-medium injection. The quantitative perfusion values of synovitis showed a good correlation with the disease activity. Perfusion values for inflamed synovium in phase of high activity were up to 230 ml/100 g tissue/min. Conclusion: The proposed modality allows for the assessment of disease activity in arthritis without the application of contrast-medium offering a new tool for therapy monitoring. As the technique provides quantitative information on hyperaemia, it potentially offers new insights in the pathophysiology of arthritic diseases.
KW - Arterial spin labeling
KW - ASL
KW - Inflammatory joint diseases
KW - Perfusion imaging
KW - Synovitis
UR - http://www.scopus.com/inward/record.url?scp=67650490170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650490170&partnerID=8YFLogxK
U2 - 10.1007/s10334-008-0162-y
DO - 10.1007/s10334-008-0162-y
M3 - Article
C2 - 19172323
AN - SCOPUS:67650490170
VL - 22
SP - 175
EP - 180
JO - Magnetic Resonance Materials in Physics, Biology, and Medicine
JF - Magnetic Resonance Materials in Physics, Biology, and Medicine
SN - 0968-5243
IS - 3
ER -