Magnetic resonance spectroscopy in major depressive disorder

Mona Mohamed, Ali Sibtain Farooq Sheikh

Research output: Contribution to journalArticle


In this paper, we have collected and discussed the current literature on MRS/MRSI techniques used in cases of depression to help understand the pathophysiology of the disease. The literature search using National Institutes of Health’s PubMed database, Scopus, and Google Scholar, provided us with 71 peer-reviewed publications to look at the disease effects amongst adolescent children, adult as well as the elderly population. Metabolite changes in N-acetyl aspartate (NAA), choline (Cho), glutamate (Glu), and Gamma Aminobutyric Acid (GABA) are quite consistent in some brain regions among comparable studies, with a few inconsistencies noted due to the different study designs.

Original languageEnglish (US)
Pages (from-to)167-187
Number of pages21
JournalInternational Journal of Emergency Mental Health
Issue number1
Publication statusPublished - 2015



  • Brain metabolites
  • Depression
  • MRS

ASJC Scopus subject areas

  • Medicine(all)
  • Psychiatry and Mental health

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